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The aim of the study is to train patients with Parkinson's Disease to increase activity in a brain area that is involved in the control of motor functions with the use of a technique called real-time fMRI neurofeedback (NF) along with regular physical exercise. This will be a randomised and controlled clinical trial to evaluate the benefits of a novel treatment. The investigators expect NF training along with physical exercise practise to better improve motor functions compared to physical exercise alone.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Neurofeedback and Physical Exercise | Experimental | This group will undergo neurofeedback intervention in the fMRI scanner in weeks 1,5 and 12. They will also undergo physical exercise training on WiiFit device once a week after the first month till the end of the study at 12 weeks. |
|
| Physical Exercise | Active Comparator | This group will undergo Physical Exercise intervention on the WiiFit device 3 times a week in the first month and once a week after the first month till the end of the study at 12 weeks. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Neurofeedback and Physical Exercise | Other |
| ||
| Physical Exercise |
| Measure | Description | Time Frame |
|---|---|---|
| Change from Baseline in the 'Movement Disorder Society - Unified Parkinson's Disease Rating Scale' (MDS-UPDRS) | Change from Baseline in the 'Movement Disorder Society - Unified Parkinson's Disease Rating Scale' (MDS-UPDRS) in 12 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Change from baseline in the 'Parkinson's Disease Questionnaire 39' (PDQ-39) | Change from baseline in the 'Parkinson's Disease Questionnaire 39' (PDQ-39) at 4 weeks | |
| Change from baseline in the 'Parkinson's Disease Questionnaire 39' (PDQ-39) | Change from baseline in the 'Parkinson's Disease Questionnaire 39' (PDQ-39) in 12 weeks |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| David Linden, MD, PhD | Cardiff University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| School of Medicine, Cardiff University | Cardiff | Wales | CF14 4XN | United Kingdom |
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| Label | URL |
|---|---|
| Paper reporting trial results | View source |
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| ID | Term |
|---|---|
| D010300 | Parkinson Disease |
| ID | Term |
|---|---|
| D020734 | Parkinsonian Disorders |
| D001480 | Basal Ganglia Diseases |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
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| ID | Term |
|---|---|
| D058765 | Neurofeedback |
| D015444 | Exercise |
| ID | Term |
|---|---|
| D001676 | Biofeedback, Psychology |
| D026441 | Mind-Body Therapies |
| D000529 | Complementary Therapies |
| D013812 | Therapeutics |
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| Other |
|
| Change from baseline in the 'Actigraph' | Change from baseline in the 'Actigraph' at 12 weeks |
| Change from baseline in the 'GaitRite' | Change from baseline in the 'GaitRite' at 12 weeks |
| D009422 | Nervous System Diseases |
| D009069 | Movement Disorders |
| D000080874 | Synucleinopathies |
| D019636 | Neurodegenerative Diseases |
| D001521 |
| Behavior Therapy |
| D011613 | Psychotherapy |
| D004191 | Behavioral Disciplines and Activities |
| D030141 | Feedback, Psychological |
| D009043 | Motor Activity |
| D009068 | Movement |
| D009142 | Musculoskeletal Physiological Phenomena |
| D055687 | Musculoskeletal and Neural Physiological Phenomena |