Korean Registry of Target Organ Damages in Hypertension

Observational Study of Clinical Characteristics and Prognostic Factors of Korean Hypertensives

The objective of this study is to know prevalence of clinical or subclinical target organ damages in Korea hypertensives by constructing nationwide hypertension registry. We will register 5000 consecutive patients with incident hypertension at 20 major university hospitals in South Korea. We will investigate clinical/subclinical target organ damages, renin/aldosterone level and cardiovascular events in each patient.

Background: the exact prevalence of target organ damages in Korean hypertensives are unknown.

Study Objective: to investigate the prevalence of target organ damages in Korean patients with incident hypertension.

Study Design: prospective, multi-center and observational study

Study Populaton: approximately 5000 consecutive patients with incident hypertension, who visited outpatients clinics and agreed to participate in the registry

Primary outcome

• Subclinical organ damages

  1. left ventricular hypertrophy on electrocardiogram or echocardiography
  2. increased intima media thickness of carotid artery (> 0.9 mm) or plaque
  3. increased pulse wave velocity (> 12 m/s)
  4. low estimated glomerular filtration rate (< 60 ml/min/1.73 m2) or creatinine clearance (<60 ml/min)

• Established CV or renal disease

  1. cerebrovascular disease: ischemic stroke; cerebral stroke; transient ischemic attack
  2. Heart disease: myocardial infarction; angina; coronary revascularization; heart failure
  3. Renal disease: diabetic retinopathy; serum creatinine M > 133, W > 124 mmol/L; proteinuria > 300 mg/24 hr
  4. Peripheral artery disease
  5. Advanced retinopathy: hemorrhage or exudates, papilledema

Inclusion Criteria:

• age≧30years
• primary incident hypertension
• singed informed consent

Exclusion Criteria:

• participated in other clinical trials