Efficacy Parecoxib and Ketorolac as Preemptive Analgesia in Spine Fusion

Comparing the Efficacy of Parecoxib and Ketorolac as Preemptive Analgesia in Patients Undergoing Posterior Lumbar Spinal Fusion

The purpose of this study is to evaluate the efficacy of Parecoxib and Ketorolac as a preemptive analgesia in patients undergoing lumbar spinal fusion.

A prospective, double-blinded randomized control trial. Randomly allocated patient undergoing posterior lumbar spinal fusion into 3 groups (n=32) to receive Parecoxib, Ketorolac and Placebo around 30 minutes prior to incised skin. Efficacy was assessed by visual analog scale score (0-10), total opioid consumption, complication and bleeding also recorded.

Inclusion Criteria:

• Patients undergoing lumbar spinal fusion for one to three levels
• ASA class I or II

Exclusion Criteria:

• History of allergy to Sulfa group
• History of allergy to OPOID or NSAIDs
• Contraindicate to NSAIDs use
• History of coagulopathy or platelet disfunction