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This study aims to investigate the effect of proton pump inhibitor on the pharmacokinetics and pharmacodynamics of metformin in healthy Korean men.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Metformin only | Experimental | metformin 750mg(D-1), metformin 500mg (D1) |
|
| Metformin and Pantoprazole | Experimental | pantoprazole 40mg(D-2)/ metformin 750mg + pantoprazole 40mg(D-1)/metformin 500mg + pantoprazole 40mg(D1) |
|
| Metformin and Rabeprazole | Experimental | rabeprazole 20mg(D-2)/metformin 750mg+rabeprazole 20mg(D-1)/metformin 500mg+rabeprazole 20mg(D1) |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Metformin | Drug |
|
| |
| Metformin and Pantoprazole |
| Measure | Description | Time Frame |
|---|---|---|
| AUC(area under the plasma concentration-time curve) | AUC(area under the plasma concentration-time curve), Cmax(maximum plasma concentration), t1/2 | Predose and 0.5, 1, 1.5, 2, 2.5, 3, 4, 6, 8, 10, 12h postdose |
| Measure | Description | Time Frame |
|---|---|---|
| AUG(total area under the serum concentration-time curve for glucose) | AUG (total area under the serum concentration-time curve for glucose) Gmax(maximum serum glucose concentration) | predose and 15, 30, 45, 60, 90, 120, 150, 180min oral glucose tolerance test |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Jae-Yong Chung, MD, PhD | Department of Clinical Pharmacology and Therapeutics, Seoul National University Bundang Hospital, Seoul, Korea | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Seoul National University Bundang Hospital | Seoul | South Korea |
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| Drug |
|
|
| Metformin and Rabeprazole | Drug |
|
|
| ID | Term |
|---|---|
| D008687 | Metformin |
| D000077402 | Pantoprazole |
| D064750 | Rabeprazole |
| ID | Term |
|---|---|
| D001645 | Biguanides |
| D006146 | Guanidines |
| D000578 | Amidines |
| D009930 | Organic Chemicals |
| D053799 | 2-Pyridinylmethylsulfinylbenzimidazoles |
| D013454 | Sulfoxides |
| D013457 | Sulfur Compounds |
| D011725 | Pyridines |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |
| D001562 | Benzimidazoles |
| D006574 | Heterocyclic Compounds, 2-Ring |
| D000072471 | Heterocyclic Compounds, Fused-Ring |
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