The purpose of this study is to investigate the pharmacokinetic drug interaction between Metformin and Rosuvastatin in healthy male volunteers.

Drug-drug Interaction Following Co-administration of Metformin and Rosuvastatin in Healthy Male Volunteers

Inclusion Criteria:

• 19~55 years healthy male
• BMI measurement 19.0kg/m^2~ 28.0kg/m^2
• Signed informed consent form from to participate voluntarily and to comply with the trial requirements.

Exclusion Criteria:

• History of clinically significant kidney, liver, gastro-intestinal system, cardiovascular system, respiratory system, tumor or blood disorders, nervous system, immune system, endocrine disorders, cardiovascular diseases, mental disorders (mood disorders, obsessive-compulsive disorder, etc.)
• SBP>140mmHg or <90mmHg, DBP>90mmHg or <60mmHg.
• An impossible one who participants in clinical trial by investigator's decision including laboratory test result or another reason.
• History of drug abuse
• A alcohol consumer(alcohol>140g/week) or smoker(cigarette>10 cigarettes/day) Hypersensitivity reaction in history of investigational drugs or specific drugs(aspirin, antibiotics)
• Administrated investigational product in a previous clinical trial within 60 days of the screening day in this study.
• Administrated drugs which can inhibit or induce OCT2, OATP1B1 transporter within 30 days of the screening day in this study.(ex: proton pump inhibitor, rifampicin)
• Glomerular filtration rate<60mL/min
• Donated blood within 60 days prior to the screening day or apheresis blood within 30 days prior to the screening day .