The primary objective of this study is to build a well characterized cohort of patients that will be used to determine the genetic variants associated with obstructive sleep apnea (OSA)and its co-morbidities.

The purpose of building the cohort is to allow the performance of genome-wide association studies with a large sample of patients that have been well-characterized using standardized procedures.

Inclusion Criteria:

We will recruit subjects who are:

• 18 years of age and older.
• Willing and able to give informed consent

AND any of the following:

• PSG (polysomnogram)requested by a physician based on clinical grounds
• AHI (Apnea-hypopnea index) ≥ 5 episodes per hour based on a prior PSG.

Exclusion Criteria:

Incapable of giving informed consent

• Under the age of 18

Adult subjects 18 years of age and older who are scheduled for polysomnography (PSG), regardless of final diagnosis AND adult subjects who have already been diagnosed with OSA based on a prior PSG and are already on treatment. OSA diagnosis will be defined as an apnea/hypopnea index (AHI) >or =5 episodes per hour.