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The purpose of this study is:
Obstructive Sleep Apnea (OSA) is a condition with important cardiovascular repercussions. However, the association between OSA, cardiovascular diseases, and obesity has not been totally clarified. We hypothesized that the cardiovascular consequences of OSA are due to obesity.
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| Measure | Description | Time Frame |
|---|---|---|
| Cardiovascular events | five years |
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Inclusion Criteria:
Exclusion Criteria:
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1000 OSA patients and 1000 controls enrolled from Instituto do Sono database 500 subjects with body mass index less than 25
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Fatima D Cintra, MD, PhD | Contact | 55 11 99698555 | fatimacintra@interair.com.br |
| Name | Affiliation | Role |
|---|---|---|
| Fatima D Cintra, PhD | Associacao Fundo de Incentivo a Psicofarmcologia | Principal Investigator |
| Dalva Poyares, PhD | Associacao Fundo de Incentivo a Psicofarmcologia | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Instituto do Sono/AFIP | Recruiting | São Paulo | São Paulo | 04516001 | Brazil |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 26071656 | Derived | Feres MC, Fonseca FA, Cintra FD, Mello-Fujita L, de Souza AL, De Martino MC, Tufik S, Poyares D. An assessment of oxidized LDL in the lipid profiles of patients with obstructive sleep apnea and its association with both hypertension and dyslipidemia, and the impact of treatment with CPAP. Atherosclerosis. 2015 Aug;241(2):342-9. doi: 10.1016/j.atherosclerosis.2015.05.008. Epub 2015 May 23. | |
| 21437515 |
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| ID | Term |
|---|---|
| D020181 | Sleep Apnea, Obstructive |
| D009765 | Obesity |
| ID | Term |
|---|---|
| D012891 | Sleep Apnea Syndromes |
| D001049 | Apnea |
| D012120 | Respiration Disorders |
| D012140 | Respiratory Tract Diseases |
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| Sergio Tufik, PhD |
| Associacao Fundo de Incentivo a Psicofarmcologia |
| Study Director |
| Derived |
| Cintra FD, Tufik S, Paola Ad, Feres MC, Melo-Fujita L, Oliveira W, Rizzi C, Poyares D. Cardiovascular profile in patients with obstructive sleep apnea. Arq Bras Cardiol. 2011 Apr;96(4):293-9. doi: 10.1590/s0066-782x2011005000030. Epub 2011 Mar 18. English, Portuguese, Spanish. |
| 19801583 | Derived | Rizzi CF, Cintra F, Risso T, Pulz C, Tufik S, de Paola A, Poyares D. Exercise capacity and obstructive sleep apnea in lean subjects. Chest. 2010 Jan;137(1):109-14. doi: 10.1378/chest.09-1201. Epub 2009 Oct 3. |
| D020919 |
| Sleep Disorders, Intrinsic |
| D020920 | Dyssomnias |
| D012893 | Sleep Wake Disorders |
| D009422 | Nervous System Diseases |
| D050177 | Overweight |
| D044343 | Overnutrition |
| D009748 | Nutrition Disorders |
| D009750 | Nutritional and Metabolic Diseases |
| D001835 | Body Weight |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |