Endometrial injury increases clinical pregnancy rate in normoresponder patients undergoing long agonist protocol intracytoplasmic sperm injection cycles with single embryo transfer.

Endometrial injury means endometrial biopsy on day 3 of menstrual cycle following down regulation in an IVF patient.

Inclusion Criteria:

• woman age under 35 years
• history of primary infertility
• normoresponder (antral follicle count 5-10 in one ovary in early follicular phase
• having grade I or II embryos for transfer
• agree to undergo endometrial biopsy during the COH cycle. All patients were stimulated with luteal phase long protocol.

Exclusion Criteria:

• endocrinopathies (including diabetes mellitus, hyperprolactinemia, Cushing's disease, and congenital adrenal hyperplasia), any systemic disease, collagen disorder, hypercholesterolemia, sickle cell anemia, and a history of neoplasm; -high risk for or history of OHSS
• using any concurrent medication (e.g., insulin-sensitizing drugs, and GnRH antagonists)
• patients who did not proceed to follicle retrieval
• severe male infertility requiring TESA/TESA
• mullerian tract anomalies
• a history of endometrial instrumentation or surgery within a month of the study
• not agree to undergo endometrial biopsy during the COH cycle.

No limitations.