Endometrial Injury and Single Embryo Transfer

Endometrial Injury May Increase the Clinical Pregnancy Rate in Normoresponders Underwent Long Agonist Protocol Intracytoplasmic Sperm Injection Cycles With Single Embryo Transfer

Endometrial injury increases clinical pregnancy rate in normoresponder patients undergoing long agonist protocol intracytoplasmic sperm injection cycles with single embryo transfer.

Endometrial injury means endometrial biopsy on day 3 of menstrual cycle following down regulation in an IVF patient.

Inclusion Criteria:

• woman age under 35 years
• history of primary infertility
• normoresponder (antral follicle count 5-10 in one ovary in early follicular phase
• having grade I or II embryos for transfer
• agree to undergo endometrial biopsy during the COH cycle. All patients were stimulated with luteal phase long protocol.

Exclusion Criteria:

• endocrinopathies (including diabetes mellitus, hyperprolactinemia, Cushing's disease, and congenital adrenal hyperplasia), any systemic disease, collagen disorder, hypercholesterolemia, sickle cell anemia, and a history of neoplasm; -high risk for or history of OHSS
• using any concurrent medication (e.g., insulin-sensitizing drugs, and GnRH antagonists)
• patients who did not proceed to follicle retrieval
• severe male infertility requiring TESA/TESA
• mullerian tract anomalies
• a history of endometrial instrumentation or surgery within a month of the study
• not agree to undergo endometrial biopsy during the COH cycle.