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| ID | Type | Description | Link |
|---|---|---|---|
| 11DZ1972703 | Other Grant/Funding Number | Shanghai Science and Technology Commission |
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The purpose of this study is to evaluate the clinical safety and efficacy of QingReMoShen Granule to treat idiopathic membranous nephropathy.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Losartan Tablets & QingReMoShen Granule | Experimental | Losartan Tablets: 50mg, qd, po. QingReMoShen Granule: 12g, tid, po. |
|
| Losartan Tablets & Placebo Granule | Placebo Comparator | Losartan Tablets: 50mg, qd, po. Placebo Granule: 12g, tid, po. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Losartan Tablets & QingReMoShen Granule | Drug |
| ||
| Losartan Tablets & Placebo Granule |
| Measure | Description | Time Frame |
|---|---|---|
| 24-hour urine protein | At the 24thweek |
| Measure | Description | Time Frame |
|---|---|---|
| serum albumin concentration | At the 24thweek | |
| eGFR | At the 24thweek | |
| Alanine transaminase |
| Measure | Description | Time Frame |
|---|---|---|
| T-cell classification | Detecting by flow cytometry method | At the 24thweek |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Lin Wang, PHD,MD | Shanghai University of Traditional Chinese Medicine | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Shanghai University of Traditional Chinese Medicine | Shanghai | Shanghai Municipality | 200032 | China |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 34778952 | Derived | von Groote TC, Williams G, Au EH, Chen Y, Mathew AT, Hodson EM, Tunnicliffe DJ. Immunosuppressive treatment for primary membranous nephropathy in adults with nephrotic syndrome. Cochrane Database Syst Rev. 2021 Nov 15;11(11):CD004293. doi: 10.1002/14651858.CD004293.pub4. |
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| ID | Term |
|---|---|
| D015433 | Glomerulonephritis, Membranous |
| ID | Term |
|---|---|
| D005921 | Glomerulonephritis |
| D009393 | Nephritis |
| D007674 | Kidney Diseases |
| D014570 | Urologic Diseases |
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| ID | Term |
|---|---|
| D019808 | Losartan |
| ID | Term |
|---|---|
| D001713 | Biphenyl Compounds |
| D001555 | Benzene Derivatives |
| D006841 | Hydrocarbons, Aromatic |
| D006844 | Hydrocarbons, Cyclic |
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| Drug |
|
| At the 24thweek |
| D052776 |
| Female Urogenital Diseases |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
| D052801 | Male Urogenital Diseases |
| D001327 | Autoimmune Diseases |
| D007154 | Immune System Diseases |
| D006838 |
| Hydrocarbons |
| D009930 | Organic Chemicals |
| D007093 | Imidazoles |
| D001393 | Azoles |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |
| D013777 | Tetrazoles |