Bariatric Surgery and Sperm Quality

Bariatric Surgery, Nutrition, and Sperm Quality of Adult Obese Men on Childbearing Age : A Multicentric Cohort Study

The purpose of this study is to evaluate the impact of a bariatric surgery (gastric banding, bypass, sleeve gastrectomy) on several parameters (quality of sperm and others biological parameters, lifestyle, quality of life) involved in fertility of obese adult men.

In order to assess how bariatric surgery may influence their fertility parameters, patients will attend to 3 visits :

First visit (inclusion, before surgery) :

• Signature of consent
• Patient interview (Collection of data on background, treatments, socio-demographic characteristics, social and familial environment, food consumption and habits, tobacco and alcohol use, physical activity, libido and quality of life (surveys))
• Clinical examination and anthropometric assessment (BMI, blood pressure, expired CO)
• Blood samples (Metabolic and nutritional plasmatic biomarkers ; Plasmatic oxidative stress biomarkers ; antioxidants micronutrients ; hormones of adiposity and inflammation ; sex hormones ; persistent contaminants)
• Sperm sample (sperm count-morphology ; DNA fragmentation ; CASA)

Bariatric surgery

Second visit (6 month follow-up)

• Report of adverse events if any
• Surveys
• Blood and sperm samples

Third visit (12 month follow-up)

• Report of adverse events if any
• Blood and sperm samples

Inclusion Criteria:

• Obese men with BMI ≥ 40kg/m² or 35 kg/m² with associated co-morbidities
• Selected for bariatric surgery by multidisciplinary team
• From 18 to 50 years old included
• With a first medical consultation and its results
• With their written informed consent to participate in the study
• No problem for understanding verbal or written French
• An affiliation to social security

Exclusion Criteria:

• Not candidates for surgery
• With non idiopathic alteration of spermatogenesis