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The purpose of this study is to investigate metabolic effects of 3 different nutritional compounds.
Fasting (36 hours) creates a catabolic state that is comparable with the catabolic state seen in acute illness.
This study is a randomized, placebo cross-over study investigating 8 healthy men on 4 separated days (at least 3 weeks between trials).
The investigators hypothesize that these nutritional supplements may counteract catabolic processes in different ways and degrees.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| control | Active Comparator | Isocaloric carbohydrate drink |
|
| low leucine content drink | Active Comparator | A soy protein drink |
|
| high content of leucine drink | Active Comparator | A whey protein drink |
|
| low leucine content + HMB drink | Active Comparator | Soy protein drink added HMB |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| low leucine content drink | Dietary Supplement |
| ||
| high leucine content drink |
| Measure | Description | Time Frame |
|---|---|---|
| Protein metabolism after 36 hours fasting receiving different nutritional supplements. | Protein metabolism is measured with amino acid tracer techniques comparing marked amino acids from blood samples. Muscle and fat biopsies are obtained for signaling analysis. Indirect calorimetry measurements are used to compare metabolism in the control period and during the intervention. | 3 control period followed by 4 hours of nutritional drink intake |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Internal Medicine and Endocrinology, Aarhus Universitetshospital | Aarhus C | 8000 | Denmark |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 37844838 | Derived | Pedersen MGB, Lauritzen ES, Svart MV, Stoy J, Sondergaard E, Thomsen HH, Kampmann U, Bjerre M, Jessen N, Moller N, Rittig N. Nutrient sensing: LEAP2 concentration in response to fasting, glucose, lactate, and beta-hydroxybutyrate in healthy young males. Am J Clin Nutr. 2023 Dec;118(6):1091-1098. doi: 10.1016/j.ajcnut.2023.10.007. Epub 2023 Oct 14. | |
| 27265181 |
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| Dietary Supplement |
|
| low leucine + HMB drink | Dietary Supplement |
|
| Control/carbohydrate | Dietary Supplement |
|
| 36 hour fasting | Behavioral |
|
| Rittig N, Bach E, Thomsen HH, Moller AB, Hansen J, Johannsen M, Jensen E, Serena A, Jorgensen JO, Richelsen B, Jessen N, Moller N. Anabolic effects of leucine-rich whey protein, carbohydrate, and soy protein with and without beta-hydroxy-beta-methylbutyrate (HMB) during fasting-induced catabolism: A human randomized crossover trial. Clin Nutr. 2017 Jun;36(3):697-705. doi: 10.1016/j.clnu.2016.05.004. Epub 2016 May 25. |
| ID | Term |
|---|---|
| D005215 | Fasting |
| ID | Term |
|---|---|
| D005247 | Feeding Behavior |
| D001519 | Behavior |
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| ID | Term |
|---|---|
| D002241 | Carbohydrates |
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