Leucine and Beta-hydroxy-beta-methylbutyrate (HMB) as Anabolic Nutrients After 36 Hours of Fasting

Leucine and Beta-hydroxy-beta-methylbutyrate (HMB) as Anabolic Nutrients After 36 Hours of Fasting

The purpose of this study is to investigate metabolic effects of 3 different nutritional compounds.

Fasting (36 hours) creates a catabolic state that is comparable with the catabolic state seen in acute illness.

This study is a randomized, placebo cross-over study investigating 8 healthy men on 4 separated days (at least 3 weeks between trials).

• High leucine content drink
• Low leucine content drink
• Low leucine content drink + HMB
• Carbohydrate (isocaloric)

The investigators hypothesize that these nutritional supplements may counteract catabolic processes in different ways and degrees.

Inclusion Criteria:

• male gender
• 20<BMI<30
• Age > 20 years old
• Written consent before starting the study

Exclusion Criteria:

• Allergy for soya products ore egg
• Diabetes
• Epilepsy
• Infection
• Immune defects
• Heart disease
• Dysregulated hypertension
• Participating in other trials using radioactive tracers or x-rays the last year.