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| Name | Class |
|---|---|
| Poitiers University Hospital | OTHER |
| Institut National de la Santé Et de la Recherche Médicale, France | OTHER_GOV |
| University Hospital, Tours | OTHER |
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The purpose of the study is to assess the dying process in critically ill patients with decision to withdraw invasive mechanical ventilation in anticipation of death and to compare effects of extubation and those of terminal weaning of mechanical ventilation on relatives and care givers. The investigators primary hypothesis is that extubation is associated with less symptoms of post-traumatic stress disorders in relatives, as compared to terminal weaning.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Withdrawal of mechanical ventilation |
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| Measure | Description | Time Frame |
|---|---|---|
| Post traumatic Stress Disorder | Post traumatic Stress Disorder as assessed by the Impact of event Scale-revised(IES-R) | three month after patient's death |
| Measure | Description | Time Frame |
|---|---|---|
| Post traumatic Stress Disorder | Post traumatic stress disorder of relatives assessed by the Impact of Event Scale -revised (IES-R) | 12 months after patient's death |
| Anxiety and depression | Anxiety and depression of the relatives, assessed by the hospital Anxiety and Depression Scale (HADS) |
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Inclusion Criteria:
Exclusion Criteria:
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Patients admitted in ICU with end of life decision to withdraw invasive mechanical ventilation after at least 48 hours of ICU stay
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| Name | Affiliation | Role |
|---|---|---|
| Jean Reignier, MD, PhD | Centre Hospitalier Départemental de la Vendée, La Roche sur Yon, France | Principal Investigator |
| René Robert, MD | Poitiers University Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Réanimation médicale CHU | Angers | 49000 | France | |||
| Réanimation, CH d'Angoulême |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 28936597 | Derived | Robert R, Le Gouge A, Kentish-Barnes N, Cottereau A, Giraudeau B, Adda M, Annane D, Audibert J, Barbier F, Bardou P, Bourcier S, Bourenne J, Boyer A, Brenas F, Das V, Desachy A, Devaquet J, Feissel M, Ganster F, Garrouste-Orgeas M, Grillet G, Guisset O, Hamidfar-Roy R, Hyacinthe AC, Jochmans S, Jourdain M, Lautrette A, Lerolle N, Lesieur O, Lion F, Mateu P, Megarbane B, Merceron S, Mercier E, Messika J, Morin-Longuet P, Philippon-Jouve B, Quenot JP, Renault A, Repesse X, Rigaud JP, Robin S, Roquilly A, Seguin A, Thevenin D, Tirot P, Vinatier I, Azoulay E, Reignier J. Terminal weaning or immediate extubation for withdrawing mechanical ventilation in critically ill patients (the ARREVE observational study). Intensive Care Med. 2017 Dec;43(12):1793-1807. doi: 10.1007/s00134-017-4891-0. Epub 2017 Sep 22. |
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| 3, 6 and 12 months after patient's death |
| Complicated grief | Complicated grief as assessed by the Inventory of Complicated Grief (ICG) scale | 6 and 12 months after patient's death |
| Relative's satisfaction | Questionnaire on relative's satisfaction | 3 months after patient's death |
| Nurse's satisfaction | Questionnaire on nurse's satisfaction | within day 1 after patient's death |
| Physician's satisfaction | Questionnaire on physician's satisfaction | within day 1 after patient's death |
| Burn out syndrome of the nurse | Burn out syndrome of the patient's nurse as assessed by the Job Strain scale | within day 1 after patient's death |
| Burn out syndrome of the physician | Burn out syndrome of the patient's physician as assessed by the Job Strain scale | within day 1 after patient's death |
| Angoulême |
| France |
| Réanimation, CH d'Annecy | Annecy | France |
| Réanimation | Belfort | France |
| CHU Pellegrin Tripode | Bordeaux | 33076 | France |
| Réanimation, CHU | Bordeaux | France |
| CHU Ambroise Paré | Boulogne | France |
| CHU La Cavale Blanche | Brest | France |
| CHU de Côte de Lumière | Caen | France |
| Centre Hospitalier, Service de réanimation | Charleville-Mézières | France |
| CH de Chartres | Chartres | France |
| CHU Gabriel Montpied, Clermont Ferrand | Clermont-Ferrand | 63003 | France |
| CHU Louis Mourier | Colombes | France |
| CH de Dieppe | Dieppe | 76202 | France |
| CHU Dijon | Dijon | 21079 | France |
| CHU Raymond Poincaré | Garches | 92380 | France |
| CHU Grenoble | Grenoble | 38043 | France |
| CHD de la Vendée | La Roche-sur-Yon | France |
| CH de La Rochelle | La Rochelle | France |
| CH du Mans | Le Mans | France |
| CH du Puy | Le Puy-en-Velay | France |
| CH Docteur Schaffner | Lens | 62307 | France |
| CHU de Lille | Lille | France |
| CH de Lorient | Lorient | France |
| CHU Marseille, Hopital La Timone | Marseille | 13000 | France |
| CHU de Marseille, Hopital Nord | Marseille | France |
| CH Marc Jacquet | Melun | 77000 | France |
| CH de Montauban | Montauban | 82013 | France |
| CHI André Grégoire | Montreuil | 93105 | France |
| CH de Mulhouse | Mulhouse | France |
| CHU de Nantes - Hôtel Dieu | Nantes | 44093 | France |
| CHU Orléans - Réanimation Médicale | Orléans | France |
| CHU Saint Louis | Paris | 75010 | France |
| CHU Paris Cochin | Paris | 75014 | France |
| Groupe Hospitalier Paris Saint Joseph | Paris | 75014 | France |
| CHU Hopital Européen Georges Pompidou | Paris | France |
| CHU Lariboisière | Paris | France |
| CHU Poitiers | Poitiers | 86021 | France |
| CH de Roanne | Roanne | France |
| Hôpital Delafontaine | Saint-Denis | 93200 | France |
| CH de Saint-Nazaire | Saint-Nazaire | France |
| Hôpital Foch | Suresnes | 92150 | France |
| CHU Tours | Tours | 37044 | France |
| Institut Gustave Roussy | Villejuif | France |
| ID | Term |
|---|---|
| D001008 | Anxiety Disorders |
| D003863 | Depression |
| D013313 | Stress Disorders, Post-Traumatic |
| D003643 | Death |
| ID | Term |
|---|---|
| D001523 | Mental Disorders |
| D001526 | Behavioral Symptoms |
| D001519 | Behavior |
| D040921 | Stress Disorders, Traumatic |
| D000068099 | Trauma and Stressor Related Disorders |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
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