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The purpose of this study is to study the impact of blood pressure on cognitive performance.
Four groups will be evaluated for possible impact of blood pressure on cognitive performance and retinal damage.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| controlled hypertension | hypertension with medication controlled | ||
| uncontrolled hypertension | non-controlled hypertension | ||
| hypertensive urgency | hypertensive urgency no previous history or antihypertensives | ||
| asymptomatic normotensive | asymptomatic normotensive control group |
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| Measure | Description | Time Frame |
|---|---|---|
| DETECT neurocognitive outcome scores (Z-scores) in association with blood pressure measures and retinal pathology (isolated retinal hemorrhage, grade III/IV hemorrhagic retinopathy) | We aim to determine the correlation (if any) between the severity of blood pressure and DETECT neurocognitive outcomes as well as the correlation (if any) between known Hypertensive retinal disease and DETECT neurocognitive outcomes. Appropriate statistical analysis will be performed to compare clinical retinal findings, BP values, and DETECT neurocognitive test outcomes. Subject level data will only be collected on the day of Emergency Department presentation. Subjects will not be followed after their initial enrollment. The study duration is projected for 12 months | 12 months |
| Measure | Description | Time Frame |
|---|---|---|
| Variance of DETECT scores (Z-score) attributed to reading level | One year study periord (12 months) |
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Inclusion Criteria:
Patients triaged to the Grady Memorial Hospital Emergency Department or Marcus Trauma Unit
Age >18 and <65
Documented history of hypertension plus one or more of the following:
Acutely elevated Emergency Department systolic blood pressure or diastolic blood pressure on 2 separate Emergency Department measurements in the absence of a history of hypertension
Normal systolic blood pressure or diastolic blood pressure in the absence of hypertension.
Exclusion Criteria:
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Emergency department patients that meet the inclusion/exclusion criteria.
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| Name | Affiliation | Role |
|---|---|---|
| Tamara Espinoza, MD | Emory University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Grady Memorial Hospital | Atlanta | Georgia | 30303 | United States |
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| ID | Term |
|---|---|
| D006973 | Hypertension |
| D012164 | Retinal Diseases |
| D060825 | Cognitive Dysfunction |
| ID | Term |
|---|---|
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
| D005128 | Eye Diseases |
| D003072 | Cognition Disorders |
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| D019965 |
| Neurocognitive Disorders |
| D001523 | Mental Disorders |