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Evidence suggests that a diet rich in plant phenolic compounds may induce beneficial vascular effects. Coffee is a good source of phenolic compounds called chlorogenic acids (CGA), however the level of CGA is reduced during the roasting process.
The aim of this study is to investigate the effect of coffee roasting on vascular response. The investigators hypothesize that coffee roasted to a lesser extent will exert a favourable vascular response over more heavily roasted coffee due to the higher levels of CGA.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| High roast coffee | Placebo Comparator | 110mg caffeine with 108 mg chlorogenic acid at start of study |
|
| Low roast coffee | Active Comparator | 110 mg caffeine with 235 mg chlorogenic acid at start of the study |
|
| Control | Placebo Comparator | 110 mg caffeine at start of study |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Low roast coffee | Dietary Supplement | Instant coffee |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Vascular response measured by flow mediated dilatation (FMD) | Change from baseline to 2 hours |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Jeremy PE Spencer | University of Reading | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Food and Nutritional Sciences | Reading | Berkshire | RG6 6AP | United Kingdom | ||
| University of Reading |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 28012692 | Derived | Mills CE, Flury A, Marmet C, Poquet L, Rimoldi SF, Sartori C, Rexhaj E, Brenner R, Allemann Y, Zimmermann D, Gibson GR, Mottram DS, Oruna-Concha MJ, Actis-Goretta L, Spencer JPE. Mediation of coffee-induced improvements in human vascular function by chlorogenic acids and its metabolites: Two randomized, controlled, crossover intervention trials. Clin Nutr. 2017 Dec;36(6):1520-1529. doi: 10.1016/j.clnu.2016.11.013. Epub 2016 Nov 30. |
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| ID | Term |
|---|---|
| D002318 | Cardiovascular Diseases |
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| ID | Term |
|---|---|
| D014867 | Water |
| ID | Term |
|---|---|
| D006878 | Hydroxides |
| D000468 | Alkalies |
| D007287 | Inorganic Chemicals |
| D000838 | Anions |
| D007477 |
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| High roast coffee |
| Dietary Supplement |
Instant coffee |
|
| Control (Caffeine dissolved in water) | Dietary Supplement | Caffeine dissolved in water |
|
| Reading |
| England |
| RG6 6UR |
| United Kingdom |
| Ions |
| D004573 | Electrolytes |
| D010087 | Oxides |
| D017601 | Oxygen Compounds |