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| Name | Class |
|---|---|
| Uppsala University | OTHER |
| Uppsala County Council, Sweden | OTHER_GOV |
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The main purpose of the study is to test whether Internet-based relapse prevention plus medication has a better protective effect compared to medication only, for persons with residual depressive symptoms who are currently in paid employment or in education. We hypothesise that during the two years following the intervention:
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| iCBT | Experimental | Internetbased cognitive behavior therapy (iCBT) aimed att preventing relapse into major depression. |
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| Control group | No Intervention | The control group in the study will fill out questionnaires every month and will be interviewed every month to detect any relapses. They will also receive feedback on there self-reported symptoms. |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| iCBT | Behavioral | Internetbased cognitive behavior therapy (iCBT) contains interventions that will help the participant to change her behavior to experience more positive reinforcement in daily life and also to challenge her negative patterns of thought. There are also information and exercices to improve sleep, increase physical activity, train mindfulness, handle anxiety and to learn about depression. |
| Measure | Description | Time Frame |
|---|---|---|
| Days absent from work due to sick leave | The total number of days that a participant has been absent from work due to sick leave (any cause). Data will be collected from the National Insurance Agency at the end of the study. | 24 month follow up |
| Change in self-reported sick leave days | Self-reported number of sick leave days during the study will be collected cumulatively every month during the study time and summarised after 24 months. | After 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24 months |
| Change in diagnostic status | Change in diagnostic status (depressive relapse) will be assessed in a telephone interview every month during the study. The definition of a relapse is to fulfill the diagnostic criteria for major depression according to the DSM-IV at any time after the study start. | After 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24 months |
| Change in depressive symptoms | Change in depressive symptoms will be measured by an internetbased version of the Montgomery-Asberg Depression Rating Scale - Self rated. The patient will fill out the questionnaire every month. | After 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24 months |
| Measure | Description | Time Frame |
|---|---|---|
| Change in health related quality of life | Health related quality of life will be measured by an internetbased version of the EQ-5D. The questionnaire will be filled out every month. | After 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24 months |
| Change in costs associated with illness |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Fredrik Holländare, PhD | Contact | +46737600700 | fredrik.hollandare@orebroll.se |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Psychiatric Research Centre | Not yet recruiting | Örebro | 70116 | Sweden |
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| ID | Term |
|---|---|
| D003863 | Depression |
| D012008 | Recurrence |
| ID | Term |
|---|---|
| D001526 | Behavioral Symptoms |
| D001519 | Behavior |
| D020969 | Disease Attributes |
| D010335 | Pathologic Processes |
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Change in costs will be measured by an internetbased version of the self-assessment scale Trimbos/iMTA questionnaire on Costs associated with Psychiatric illness (TIC-P). |
| Pre- and post treatment, after 12 and 24 months |
| Psychiatric Clinic in Uppsala | Recruiting | Uppsala | 751 85 | Sweden |
|
| D013568 |
| Pathological Conditions, Signs and Symptoms |