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The eradication rates of first-line treatment for Helicobacter pylori(Hp) infection are not satisfactory. The study aims to compare the efficacy and safety between quadruple therapy with furazolidone and dual therapy with high doses of amoxicillin as rescue regimens for Hp.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Group RBLF | Active Comparator | receive a 14-day quadruple therapy,including rabeprazole(10mg bid),bismuth citrate(220mg bid),levofloxacin(200mg qm) and furazolidone(100mg bid). |
|
| Group RA | Active Comparator | receive a 14-day dual therapy with high doses of rabeprazole(20mg bid) and amoxicillin(1000mg tid). |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| RBLF | Drug | The patients in Group RBLF will receive a 14-day quadruple therapy,including rabeprazole(10mg bid),bismuth citrate(220mg bid),levofloxacin(200mg qm) and furazolidone(100mg bid). |
| Measure | Description | Time Frame |
|---|---|---|
| 13C-urea breath test | When the outcome of 13C-urea breath test is more than 4%, the helicobacter pylori infection is still exist(positive). | 4 weeks after treatment |
| Measure | Description | Time Frame |
|---|---|---|
| scale analysis of drug safety | 4 weeks after treatment |
| Measure | Description | Time Frame |
|---|---|---|
| 13C-urea breath test | baseline |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| xiaobo Li, MD | RenJi Hospital | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Shanghai Renji Hospital | Shanghai | Shanghai Municipality | China |
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| RA | Drug | The patients in Group RA will be sent to a penicillin skin test before treatment except they were given penicillin before. They will receive a 14-day dual therapy with high doses of rabeprazole(20mg bid) and amoxicillin(1000mg tid). |
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