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Bronchiectasis is clinically characterized by irreversible dilation of the bronchi and bronchioles leading to persistent cough, purulent sputum, and airway ļ¬ow limitation, which may be accompanied by recurrent exacerbations.It has been increasingly recognized that respiratory viruses are mainly responsible for acute exacerbation of chronic pulmonary diseases, i.e. asthma, chronic obstructive pulmonary disease and cystic fibrosis. However,little is known about the roles of viral infection in driving exacerbations of bronchiectasis.This study aims to identify the frequency of common viral infections and determine the roles that viruses play in acute exacerbations of bronchiectasis.
Bronchiectasis is a chronic airway disease characterised by a vicious cycle of persistent bacterial colonization,inflammation and progressive tissue destruction.Patients with bronchiectasis frequently developed acute exacerbations characterised by acute worsening requiring changes in concomitant use of medication,with attendant adverse effects on their morbidity and health-related quality of life. The detailed pathogenesis of exacerbations of bronchiectasis, however, remains poorly understood.
Recent data suggested that airway infection and inflammation are important drivers of exacerbations,therefore the imbalance between chronic bacterial infection and host immune response may result in bronchiectasis exacerbations. Viral infection may be an important factor that leads to this events.It has been established that respiratory viruses are mainly responsible for the exacerbations of other chronic respiratory diseases, i.e. asthma, COPD and cystic fibosis. However, the data regarding prospective studies that sought to investigate the roles of viruses in acute exacerbation of bronchiectasis are lacking. Furthermore,the associations between viruses and bacteria during exacerbation need to be assessed. This study targets at indentifying the frenquency of common viral infections in adults with non-cystic fibrosis bronchiectasis and may shed light on the effects they have on clinical parameters,i.e. the length of exacerbated symptom to recovery,lung function, pulmonary inflammation, bacterial load and quality of life.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Bronchiectasis,stable | A patient was defined as stable if there was no exacerbation for the previous 4 wk | ||
| Bronchiectasis,exacerbations | Bronchiectasis exacerbations were defined by subjective and persistent(>24 h) deterioration in at least three respiratory symptoms, including cough, dyspnea, hemoptysis, increased sputum purulence or volume, chest pain (with or without fever), radiographic deterioration, systemic disturbances, or changes in chest auscultation |
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| Measure | Description | Time Frame |
|---|---|---|
| The prevalence of respiratory virus infection in adults with bronchiectasis during a pulmonary exacerbation and when clinically stable. | Respiratory viruses in the nasal swab and sputum will be identified using the polymerase chain reaction(PCR)technique when clinically stable and during exacerbation.The following viruses will be tested for:influenza A,B(including influenza A H1N1),respiratory syncytial virus(RSV),Enterovirus,Parainfluenza 1-4,Rhinovirus,human Coronaviruses(subtypes OC43ć229EćHKU1),human metapneumovirus,adenovirus, human bocavirus,chlamydia,mycoplasma. | 1 year |
| Measure | Description | Time Frame |
|---|---|---|
| The effect of respiratory virus infection on systemic and pulmonary inflammatory markers. | Systemic and airway inflammatory cytokines including IL-1Ī²ćIL-6ćIL-8ćTNF-a were measured using a commercial multiplex bead-based assay. | 1 year |
| The effect of respiratory virus on lung function |
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Inclusion Criteria:
Exclusion Criteria:
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Adults with non-CF bronchiectasis diagnosed by High Resolution CT(HRCT) attending the out-patient clinics of First Affiliated Hospital of Guangzhou Medical University,Guangzhou,Guangdong,China
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Rongchang Chen, MD | Contact | 020-83062718 | Chenrc@Vip.163.com | |
| Nanshan Zhong, MD | Contact | 020-83062718 | nanshan@vip.163.com |
| Name | Affiliation | Role |
|---|---|---|
| Rongchang Chen, MD | The First Affiliated Hospital of Guangzhou Medical University | Principal Investigator |
| Nanshan Zhong, MD | The First Affiliated Hospital of Guangzhou Medical University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| The First Affiliated Hospital of Guangzhou Medical University | Recruiting | Guangzhou | Guangdong | 510000 | China |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 25412225 | Derived | Gao YH, Guan WJ, Xu G, Lin ZY, Tang Y, Lin ZM, Gao Y, Li HM, Zhong NS, Zhang GJ, Chen RC. The role of viral infection in pulmonary exacerbations of bronchiectasis in adults: a prospective study. Chest. 2015 Jun;147(6):1635-1643. doi: 10.1378/chest.14-1961. |
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| ID | Term |
|---|---|
| D001987 | Bronchiectasis |
| D014777 | Virus Diseases |
| ID | Term |
|---|---|
| D001982 | Bronchial Diseases |
| D012140 | Respiratory Tract Diseases |
| D007239 | Infections |
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serum
Spirometric indices in the present study is referred to as forced expiratory vilume in 1s(FEV1),forced vital capacity(FVC).Spirometry tests are carried out using a spirometer (COSMED, QUARK PFT, Italy). All operation procedures meet the joint recommendation by ATS and ERS. A total of at least 3 (not more than 8) spirometric maneuvers are performed, with the variation between the best two maneuvers of <5% or 200ml in FVC and FEV1. The maximal values of FVC and FEV1 are reported. |
| 1 year |
| The effect of respiratory virus infection on the bacterial load in bronchiectasis. | Type of bacterial infection, also referred to as potentially pathogenic organisms, and bacterial load, as expressed in cfu per mililiter | 1 year |
| Time to recovery of respective symptom | The time from exacerbation onset by which a 3-d moving average was equal to or exceeded the baseline value | 1 year |
| The effect of respiratory virus on quality of life in patients with bronchiectasis | Quality of life in patients with bronchiectasis were measured by St.George Respiratory QuestionnairećLeicester Cough Questionnaire and COPD assessment test during exacerbations,and then compared between virus-postive and virus-negative patients | 1 year |
| To investigate if upper respiratory tract symptoms are associated with viral infections. | 1 year |