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The aim of this study is to evaluate the signs of nephronic reduction in preterm infants who have presented neonatal acute renal failure. The investigators hypothesize that signs of nephronic reduction would appear earlier in former preterm with neonatal acute renal failure than in control preterm infants.
50 former preterm infants who presented acute renal failure will be evaluated between 3 to 10 years.
They will be compared to 25 control former preterm infants without renal dysfunction for signs of nephronic reduction.
At inclusion, in order to analyse renal function, all infants will have blood sampling, renal echography and blood pressure measurement. Urine sample will also be collected.
Two months later, parents will be informed on the results.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| cases with neonatal acute renal failure in preterm | Experimental |
| |
| controls without neonatal acute renal failure in preterm | Other |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| renal echography | Other | renal echography to analyse the kidney |
|
| Measure | Description | Time Frame |
|---|---|---|
| microalbuminuria | The primary outcome of this study is to prove that former preterm infants with neonatal acute renal failure are at higher risk of nephronic reduction than control former preterm infants and that they will present microalbuminuria as earlier sign of nephronic reduction. Precisely, if microalbuminuria divided by creatinuria is above 20mg/g or 2mg/mmol, it will be considered as pathologic. | Day 1 (at inclusion) |
| Measure | Description | Time Frame |
|---|---|---|
| measurement of blood pressure | Evaluation of other renal parameters: blood pressure, renal filtration, tubular functions evaluation of renal size and differentiation by ultrasound | Day 1 (at inclusion) |
| measurement of length and volume of kidney by renal echography |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Emma ALLAIN-LAUNAY, PH | Nantes University Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| CHU of Nantes | Nantes | 44093 | France |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 27335060 | Derived | Bruel A, Roze JC, Quere MP, Flamant C, Boivin M, Roussey-Kesler G, Allain-Launay E. Renal outcome in children born preterm with neonatal acute renal failure: IRENEO-a prospective controlled study. Pediatr Nephrol. 2016 Dec;31(12):2365-2373. doi: 10.1007/s00467-016-3444-z. Epub 2016 Jun 22. |
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| ID | Term |
|---|---|
| D058186 | Acute Kidney Injury |
| ID | Term |
|---|---|
| D051437 | Renal Insufficiency |
| D007674 | Kidney Diseases |
| D014570 | Urologic Diseases |
| D052776 | Female Urogenital Diseases |
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| ID | Term |
|---|---|
| D001800 | Blood Specimen Collection |
| ID | Term |
|---|---|
| D013048 | Specimen Handling |
| D019411 | Clinical Laboratory Techniques |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
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| Blood sampling | Other | Blood sampling to analyse different parameters of renal function |
|
| collection of an urine sample | Other | Collection of an urine sample to perform analysis of renal function parameters |
|
| Blood pressure measurement | Other |
|
| day 1 |
| creatinine clearance | day 1 |
| calciuria | Day 1 |
| sodium clearance | day 1 |
| D005261 |
| Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
| D052801 | Male Urogenital Diseases |
| D011677 | Punctures |
| D013514 | Surgical Procedures, Operative |
| D008919 | Investigative Techniques |