Nephronic Reduction After Neonatal Acute Renal Failure in Preterm

Renal Prognosis of Former Preterm Infants 3 to 10 Years After Neonatal Acute Renal Failure

The aim of this study is to evaluate the signs of nephronic reduction in preterm infants who have presented neonatal acute renal failure. The investigators hypothesize that signs of nephronic reduction would appear earlier in former preterm with neonatal acute renal failure than in control preterm infants.

50 former preterm infants who presented acute renal failure will be evaluated between 3 to 10 years.

They will be compared to 25 control former preterm infants without renal dysfunction for signs of nephronic reduction.

At inclusion, in order to analyse renal function, all infants will have blood sampling, renal echography and blood pressure measurement. Urine sample will also be collected.

Two months later, parents will be informed on the results.

Inclusion Criteria:

• For both group of cases (50 infants having presented acute renal failure in preterm) AND group of control cases (25 infants without this) :former preterm infant born before 33 weeks of gestational age between january 2003 and june 2010 and hospitalized in the neonatal intensive care unit of Nantes University Hospital.
• Specific to cases: neonatal acute renal failure: serum creatinine>130 micromol/l from the third day of life.
• Control cases: no such renal dysfunction

Exclusion Criteria:

• no parental consent
• other causes of renal failure: congenital uropathy, congenital nephropathy
• congenital cardiopathy, polymalformative syndrome