Long-term Renal Prognosis of Neonatal Acute Kidney Injury

Long-term Renal Prognosis of Neonatal Acute Kidney Injury: A Multicenter, Prospective Cohort Study

The goal of this observational study is to conduct a multicenter, prospective neonatal acute kidney injury (AKI) follow-up cohort to describe the clinical characteristics of chronic kidney disease (CKD) in AKI cases within 1 year of follow-up and screen for effective biomarkers that can early warn of CKD progression. Ultimately, a neonatal AKI adverse prognosis warning model based on multidimensional data will be established to provide new data and new models for CKD management.

Inclusion Criteria:

• Delivered in this hospital and subsequently admitted to the NICU during the study period;
• Diagnosed with neonatal AKI according to the 2015 KDIGO neonatal AKI criteria;
• Age <28 days.

Exclusion Criteria:

• Severe hydronephrosis diagnosed by prenatal renal ultrasound;
• Patients with congenital urinary malformations, including solitary kidney, cystic dysplasia, multicystic dysplastic kidney, renal dysplasia, and obstructive uropathy;
• Newborns who required congenital heart surgery within the first 7 days after birth;
• Newborns whose mothers had a history of renal failure;
• Death within 48 hours after birth;
• Other genetic syndromes or medical conditions were not eligible for inclusion according to the attending neonatologist's judgment.