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| ID | Type | Description | Link |
|---|---|---|---|
| SPS 181258 | Registry Identifier | Sponsored Programs |
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The investigators will simulate the conditions of a working, helmeted diver by using exercising, "head out" immersed subjects to test the following hypotheses:
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| dive to 122 feet, no exercise | Experimental | Subjects will undergo a simulated dive to a maximum depth of 122 feet of seawater with no exercise at depth |
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| dive to 158 feet, no exercise | Experimental | Subjects will undergo a simulated dive to a maximum depth of 154 feet of seawater with no exercise at depth |
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| dive to 122 feet, exercise | Experimental | Subjects will undergo a simulated dive to a maximum depth of 122 feet of seawater with exercise at depth |
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| dive to 158 feet, exercise | Experimental | Subjects will undergo a simulated dive to a maximum depth of 154 feet of seawater with exercise at depth. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| NO exercise at depth | Other | Subjects will NOT exercise while at depth |
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| Measure | Description | Time Frame |
|---|---|---|
| Is cognitive ability different while resting versus compared to cognitive ability while diving, breathing different gas mixtures and while exercising? | Subjects will undergo computerized cognitive testing before, during and after a simulated dive in the Duke Hyperbaric Chamber. Different exercise conditions (rest or exercise) and different breathing gas mixtures (added carbon dioxide or not)will be assessed and compared to the pre-dive conditions. | pre-dive to dive to post-dive (approximately 2 hours) |
| Measure | Description | Time Frame |
|---|---|---|
| How does exhaled (end tidal) carbon dioxide compare with arterial carbon dioxide? | Exhaled (end tidal) carbon dioxide will be compared to arterial carbon dioxide at the various experimental conditions of the study (at the surface versus during the dive, during exercise versus during rest, breathing gas with added carbon dioxide versus breathing gas without added carbon dioxide) | pre-dive to dive to post dive (approximately 2 hours) |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| John J Freiberger, MD | Duke University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Duke Center for Hyperbaric Medicine and Environmental Physiology | Durham | North Carolina | 27710 | United States |
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| ID | Term |
|---|---|
| D006935 | Hypercapnia |
| D009043 | Motor Activity |
| D007222 | Inert Gas Narcosis |
| D060825 | Cognitive Dysfunction |
| D053608 | Stupor |
| ID | Term |
|---|---|
| D012818 | Signs and Symptoms, Respiratory |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D001519 | Behavior |
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| exercise at depth | Other | Subjects will exercise while at depth |
|
| D009784 | Occupational Diseases |
| D005739 | Gas Poisoning |
| D011041 | Poisoning |
| D064419 | Chemically-Induced Disorders |
| D003072 | Cognition Disorders |
| D019965 | Neurocognitive Disorders |
| D001523 | Mental Disorders |
| D014474 | Unconsciousness |
| D003244 | Consciousness Disorders |
| D019954 | Neurobehavioral Manifestations |
| D009461 | Neurologic Manifestations |
| D009422 | Nervous System Diseases |