Probiotic Administration and Perennial Allergic Rhinitis

Effect of Probiotic Lactobacillus Paracasei NCC2461 on House Dust Mite Allergy

The purpose of this study is to evaluate the efficacy of a probiotic strain in improving the quality of life in adult subjects suffering from perennial allergic rhinit.

Inclusion Criteria:

• Adults between 20-65 years old
• Confirmed allergy (allergic rhinitis) to dust mite for more than 2 years, as determined by anamnesis and by a miniRQLQ of ≥ 1
• Positive Skin prick testing measure greater than 3mm wheal diameter to the dermatophagoides pteronyssinus species of house dust mite extract
• Body Mass Index 19-29
• Having obtained his/her informed consent

Exclusion Criteria:

• Anemia
• Allergy to any food or medication
• Asthma
• Family history of congenital immunodeficiency or chronic consumption (more than one week at Screening) of immunosuppressive or anti-inflammatory treatments
• Ongoing treatment with antibiotics or undergoing allergen immunotherapy at Screening
• Consumption of probiotic and other dietary nutritional interventions
• More than 2 drinks/day alcohol consumption or use of illicit drugs
• Pregnant women
• Subjects with expected low compliance
• Blood donation in the past month or planning to donate blood until a month after the end of the study
• Currently participating or having participated in another interventional clinical trial during the last four weeks prior to the beginning the study