Immune-modulatory Effect of Probiotic Strain on Grass Pollen Allergic Individuals

Immune-modulatory Effect of Candidate Probiotic Strain on Whole Blood Cells of Grass Pollen Allergic Individuals

The purpose of the current study is to evaluate the effect of administering a probiotic strain on allergic symptoms and immune parameters (Th-2 cytokines, effector cells) in seasonal allergic rhinitis subjects.

To identify immune markers in allergic individuals that are impacted by probiotic treatment during seasonal exposure

Inclusion Criteria:

• Confirmed allergy (allergic rhinitis) to grass pollen > 1 year and positive SPT > 3mm wheal diameter to grass pollen.
• Age 20-65 years adults
• Body Mass Index 19- 29 (people in the normal and overweight range)
• Having obtained his/her informed consent.

Exclusion Criteria:

• Anemia

• Family history of congenital immunodeficiency

• Regular consumption of immunosuppressive or anti-inflammatory treatment

• Under medication against allergy (e.g. anti histaminic)

• Avoid regular consumption of probiotic and other dietary nutritional interventions

• Have a high alcohol consumption (more than 1 drink/day)

• Consumption of illicit drugs

• Pregnancy

  • Subject who cannot be expected to comply with the study procedures, including consuming the test products
  • Currently participating or having participated in another clinical trial during the last 4 weeks prior to the beginning of this study