Assessment of Autonomic Neuronal Changes During Moderate Rise of Intracranial Pressure in Human

Assessment of Autonomic Neuronal Changes During Moderate Rise of Intracranial Pressure in Human

The purpose of this project is to determine during moderate rise of intracranial pressure (ICP) in awake patient, the change in autonomic function and its influence on cerebral and systemic haemodynamics.

From preliminary data, we know that changes in ICP influences both systemic and cerebral haemodynamics, introducing the concept of intracranial baroreflex We have to i) confirm the presence of this intracranial baroreflex, ii) analyze the changes in autonomic function during moderate rise in intracranial pressure (ICP) in human, and iii) correlate the changes in cerebral and systemic haemodynamics with autonomic function.

Inclusion Criteria:

• patient suspect of hydrocephalus with gait problems, urine incontinence and mild cognitive impairment.
• signed consent

Exclusion Criteria:

• psychiatric problems
• severe cognitive decline