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Ventilator acquired pneumonia (VAP) are severe nosocomial infections. On the other side, bronchial fungi colonization is commonly observed in ICU; therefore, the investigators propose to study the role of bronchial fungi colonization on the occurrence of VAP taking into account the immune status of the patient and the antibiotic and antifungal treatments he has received.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| ventilated patient | Experimental | all patients underwent the same diagnostic test . cutaneous, rectal, nose and mouth swabs to identify potential fungi colonization. HLA DR antigen, cytokines (IL 6 and 10), B-glucan. fungi and bacteria endotracheal aspiration |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| biological sampling | Procedure | cutaneous, rectal, nose and mouth swabs to identify potential fungi colonization |
|
| Measure | Description | Time Frame |
|---|---|---|
| Onset of a late ventilator acquired pneumonia (VAP) | Participants will be followed for the duration of mechanical ventilation, an expected time frame that can go from 5 days to up to 8 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Onset of a pseudomonas aeruginosa associated VAP | Participants will be followed for the duration of mechanical ventilation, an expected time frame that can go from 5 days to up to 8 weeks | |
| Onset of late ventilator associated pneumonia associated to staphylococcus aureus |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| TIMSIT Jean-François, PU/PH | University Hospital, Grenoble | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hospital University Clermont Ferrand Gabriel Montpied | Clermont-Ferrand | 63001 | France | |||
| University Hospital of Grenoble |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 31020361 | Derived | Timsit JF, Schwebel C, Styfalova L, Cornet M, Poirier P, Forrestier C, Ruckly S, Jacob MC, Souweine B. Impact of bronchial colonization with Candida spp. on the risk of bacterial ventilator-associated pneumonia in the ICU: the FUNGIBACT prospective cohort study. Intensive Care Med. 2019 Jun;45(6):834-843. doi: 10.1007/s00134-019-05622-0. Epub 2019 Apr 24. |
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| ID | Term |
|---|---|
| D053717 | Pneumonia, Ventilator-Associated |
| ID | Term |
|---|---|
| D000077299 | Healthcare-Associated Pneumonia |
| D003428 | Cross Infection |
| D007239 | Infections |
| D011014 | Pneumonia |
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| ID | Term |
|---|---|
| D017218 | Cordocentesis |
| ID | Term |
|---|---|
| D001800 | Blood Specimen Collection |
| D013048 | Specimen Handling |
| D019411 | Clinical Laboratory Techniques |
| D019937 | Diagnostic Techniques and Procedures |
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| sampling blood | Procedure | HLA DR antigen, cytokines (IL 6 and 10), B-glucan |
|
| endotracheal aspiration | Procedure | fungi and bacteria endotracheal aspiration |
|
| Participants will be followed for the duration of mechanical ventilation, an expected time frame that can go from 5 days to up to 8 weeks |
| Grenoble |
| 38043 |
| France |
| D012141 |
| Respiratory Tract Infections |
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |
| D007049 | Iatrogenic Disease |
| D020969 | Disease Attributes |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D003933 | Diagnosis |
| D019152 | Paracentesis |
| D011677 | Punctures |
| D013812 | Therapeutics |
| D013514 | Surgical Procedures, Operative |
| D008919 | Investigative Techniques |