The Study to Evaluate Efficacy and Safety of Candesartan vs Losartan in Hypertension With Heart Failure (HONOR)

Randomized, Open-label, Phase 4 Study to Evaluate Efficacy and Safety of Candesartan and Losartan in the Patients With Hypertension and Heart Failure.

The purpose of this study is to compare efficacy and safety of candesartan and losartan in hypertension with heart failure.

This is a randomized, open-label, phase 4 study. wash out periods need at least 14 days if the patients take ARB or ACE inhibitor to control Blood pressure. Patients take Candemore or Cozzar once a day during 16 weeks.

Inclusion Criteria:

• Female and male patients who aged above 19 and below 75
• Patients with 90~109mmHg average sitting DBP on baseline
• NYHA class 2~4
• Patients who agreement with written informed consent

Exclusion Criteria:

• above 110mmHg sitting DBP and/or 180mmHg sitting SBP
• Patients who have difference values that above 20mmHg sitting SBP or 10mmHg sitting DBP in both arms on screening
• Patients who have medical history that secondary hypertension or rule out secondary hypertension
• malignant hypertension
• symptomatic postural hypotension
• right heart failure due to pulmonary disease
• etc.