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To compare and evaluate the efficacy and safety of Candemore tab. versus Atacand tab. on blood pressure in patients with hypertension diagnosed congestive heart failure
This is an open label, randomized, active drug comparative, Parallel group, Multi-center, phase IV study. Patients receive candemore tablet or atacand tablet. Initial dose is 4mg/day or 8mg/day. Every 2 weeks, patients take double dose if patients blood pressure is measured SBP ≥ 100mmHg and DBP > 60mmHg. Maximum dose is 16mg/day.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Candemore tablet | Experimental | Candemore tablet
|
|
| Atacand tablet | Active Comparator | Atacand tablet
|
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Candemore tablet | Drug |
|
| Measure | Description | Time Frame |
|---|---|---|
| Mean sitting Systolic Blood Pressure | After 12 weeks of treatment |
| Measure | Description | Time Frame |
|---|---|---|
| Mean Sitting Diastolic Blood Pressure | After 12 weeks of treatment | |
| echocardiography | Left Ventricle Volume, Left Ventricle Ejection Fraction, E/E' ration, Peak TR velocity | After 12 weeks of treatment |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| KeeSik Kim, M.D Ph.D | Daegu Catholic University Medical Center | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Inje university pusan hospital | Busan | Busanjin-gu Gaegum-dong | 614-735 | South Korea | ||
| Gyeongsang national university hospital |
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| Atacand tablet | Drug |
|
|
| Blood Creatinine and Potssium level | After 4 and 12 weeks of treatment |
| NYHA class | After 12 weeks of treatment |
| Jinju |
| Chiram-dong |
| 660-702 |
| South Korea |
| Daegu fatima hospital | Daegu | Dong-gu Sinam-dong | 701-724 | South Korea |
| Daedong hospital | Busan | Dongnae-gu Myeongnyun-dong | 607-711 | South Korea |
| Inje university haeundae paik hospital | Busan | Haeundae-gu Heaundae-ro 875 | 612-030 | South Korea |
| Maryknoll medical center | Busan | Jung-gu Daecheong-dong | 600-730 | South Korea |
| Keimyung university dongsan medical center | Daegu | Jung-gu Dongsan-dong | 700-712 | South Korea |
| Kyungpook national university hospital | Daegu | Jung-gu Samdeok-dong | 700-721 | South Korea |
| Samsung changwon hospital | Changwon | Masanhoiwon-gu Hapseong-dong 50 | 630-723 | South Korea |
| Yeungnam university medical center | Daegu | Nam-gu Daemyeong-dong | 705-717 | South Korea |
| Daegu catholic univ. medical center | Daegu | Nam-gu Daemyung-dong | 705-718 | South Korea |
| Kosin university gospel hospital | Busan | Seo-gu Amnam-dong | 602-702 | South Korea |
| Dong-A university medical center | Busan | Seo-gu Dongdaesin-dong | 602-715 | South Korea |
| Dongguk university gyeongju hospital | Gyeongju | Seokjang-dong | 780-350 | South Korea |
| ID | Term |
|---|---|
| D006973 | Hypertension |
| D006333 | Heart Failure |
| D000075222 | Essential Hypertension |
| ID | Term |
|---|---|
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
| D006331 | Heart Diseases |
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| ID | Term |
|---|---|
| C077793 | candesartan cilexetil |
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