Clinical and Economic Impact of an Electronic Medical Record Interfaced Decision Support System for Minimizing Severe Drug-Drug Interactions

Leumit Health Services, an health maintenance organization operating in Israel, will incorporate a web-based, decision support system for handling drug-drug interactions and drug information, termed DDI+. the investigators hypothesize that implementing such a system will reduce health-care expenditures (e.g., hospital admissions, referrals to ERs, Imaging procedures).

Inclusion Criteria:

• Number of chronic concomitant drugs ≥5

Exclusion Criteria:

• Patients diagnosed with HIV/AIDS, and/or viral hepatitis B or C.