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Anxiety disorders are highly prevalent among those with substance use disorders, but the majority of addictions treatment centers provide little to no evidence-based treatment for anxiety disorders. Furthermore, tension reduction models suggest that treating anxiety should also improve substance use outcomes. This study is aimed at improving symptoms for people who have substance use and anxiety problems. The study is comparing regular Intensive Outpatient treatment for addiction to Intensive Outpatient treatment for addiction plus treatment for anxiety disorders. Clinicians at a community addictions clinic will participate by receiving training in delivering cognitive behavioral therapy for anxiety disorders and will deliver the treatment to the patient participants. They will also complete some questionnaires. Patient participants will be asked to complete a baseline assessment. Those who are eligible will be randomly assigned to one of the two treatment groups. Those who are assigned to addiction treatment as usual will continue their regular care at the Matrix Institute. Participants who are assigned to also receive the anxiety treatment will be asked to participate in 6, 90-min treatment sessions and an orientation session. All participants will be asked to complete post-treatment and follow-up assessments. The assessments should take approximately 1 hour, and the follow-up assessment will be completed 6 months after treatment is over. It is hypothesized that those who get the additional anxiety disorder treatment will show greater improvement in anxiety and substance use outcomes than those who get Intensive Outpatient Program without the anxiety disorder treatment.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| CALM-SUD | Experimental | Participants receive the adaptation of the Coordinated Anxiety Learning and Management (CALM) protocol that demonstrated effectiveness in a large primary care sample. CALM will be adapted for those with anxiety and substance use disorder comorbidity, and will consist of an orientation session and 6 group treatment sessions. These participants will also receive substance abuse treatment as usual at a community Intensive Outpatient Program. |
|
| Treatment as usual | Active Comparator | Participants in this arm receive the standard Intensive Outpatient treatment for their substance use disorder at a community addictions treatment facility. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| CALM-SUD | Behavioral | 6-session group for anxiety disorders. Cognitive behavioral therapy including self-monitoring, relaxation, cognitive restructuring, exposure therapy, and relapse prevention. In addition, participants in this arm are also enrolled in an Intensive Outpatient Program for their substance use disorder. The program is run by an outpatient addictions facility and includes up to 16 weeks of groups that meet 3 to 4 times per week in addition to up to 10 individual sessions of therapy. The group model includes motivational interviewing, cognitive behavioral therapy, contingency management, and relapse prevention skills. |
| Measure | Description | Time Frame |
|---|---|---|
| Brief Symptom Inventory | Change over time is being assessed. | baseline, 6 weeks, 6 months |
| Timeline Follow Back | Change over time is being assessed | baseline, 6 week, 6 month |
| Overall Anxiety Severity and Impairment Scale | Change over time is being assessed. | baseline, 6 week, 6 month |
| Measure | Description | Time Frame |
|---|---|---|
| urine toxicology screen | Change over time is being assessed. | baseline, 6 week, 6 month |
| Patient Health Questionnaire-8 | brief depression measure; Change over time is being assessed. |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Kate B Taylor, Ph.D. | University of Southern California | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Matrix Institute on Addictions | Los Angeles | California | 90025 | United States | ||
| University of California-Los Angeles, Department of Psychiatry and Biobehavioral Sciences |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 29852309 | Derived | Wolitzky-Taylor K, Drazdowski TK, Niles A, Roy-Byrne P, Ries R, Rawson R, Craske MG. Change in anxiety sensitivity and substance use coping motives as putative mediators of treatment efficacy among substance users. Behav Res Ther. 2018 Aug;107:34-41. doi: 10.1016/j.brat.2018.05.010. Epub 2018 May 24. | |
| 29300100 | Derived | Wolitzky-Taylor K, Krull J, Rawson R, Roy-Byrne P, Ries R, Craske MG. Randomized clinical trial evaluating the preliminary effectiveness of an integrated anxiety disorder treatment in substance use disorder specialty clinics. J Consult Clin Psychol. 2018 Jan;86(1):81-88. doi: 10.1037/ccp0000276. |
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| ID | Term |
|---|---|
| D001008 | Anxiety Disorders |
| D019966 | Substance-Related Disorders |
| ID | Term |
|---|---|
| D001523 | Mental Disorders |
| D064419 | Chemically-Induced Disorders |
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| ID | Term |
|---|---|
| D013812 | Therapeutics |
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|
| Treatment as usual | Behavioral | The program is run by an outpatient addictions facility and includes up to 16 weeks of groups that meet 3 to 4 times per week in addition to up to 10 individual sessions of therapy. The group model includes motivational interviewing, cognitive behavioral therapy, contingency management, and relapse prevention skills. |
|
| baseline, 6 week, 6 month |
| Anxiety Sensitivity Index | Change over time is being assessed. | baseline, 6 week, 6 month |
| Panic Disorder Severity Scale | Change over time is being assessed. | baseline, 6 week, 6 month |
| Social Phobia Inventory | Change over time is being assessed. | baseline, 6 week, 6 month |
| Penn State Worry Questionnaire | Change over time is being assessed. | baseline, 6 week, 6 month |
| Posttraumatic Stress Disorder Checklist | Change over time is being assessed. | baseline, 6 week, 6 month |
| Los Angeles |
| California |
| 90025 |
| United States |