Comparison of the Efficacy and Safety of Closone and Clopidogrel With Aspirin

Comparison of the Efficacy and Safety of Closone and Clopidogrel With Aspirin in Korean Patients With Coronary Artery Disease (a Single-center, Randomized, Open-label Clinical Trial)

The Aim of this study is to prove non-inferiority of Closone to the Combination treatment of Plavix with Astrix.

Inclusion Criteria:

• Subjects under condition after Post-Percutaneous Coronary Artery Intervention over twelve months
• 20~85 years old
• Willing to adhere to protocol requirements and sign a informed consent form

Exclusion Criteria:

• Subject who did not undergo or failed Stent Implantation

• Subjects who took an anti-coagulant, anti-thrombotic regularly before the study, or plan to have continuous treatment during the study

• Subjects with a history of hypersensitivity to Clopidogrel, Aspirin

• Subjects with uncontrolled severe hypertension

• Subjects with high risk of hemorrhage like blood coagulation disorders

  :gastrointestinal bleeding, gross hematuria, intraocular bleeding, hemorrhagic stroke, intracranial hemorrhage

• Subjects with intractable arrhythmia, intracranial hemorrhage

• Subjects with Severe cardiomyopathy (New York Heart Association(NYHA) Class Ⅳ)

• Subjects with Severe hepatopathy(AST and ALT > 10 times the upper limit of normal)

• Subjects who are pregnant, breastfeeding and not using medically acceptable birth control

• Subjects considered as unsuitable based on medical judgement by investigators