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| Name | Class |
|---|---|
| CKD Pharmaceutical Limited | UNKNOWN |
The purpose of this study is to compare the efficacy and tolerability between clopidogrel resinate and clopidogrel bisulfate in patients with coronary heart disease (CHD) or CHD equivalents.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| aspirin+placebo | Placebo Comparator | aspirin protect (Bayer) 100mg + placebo clopidogrel 75mg for 1mo |
|
| aspirin+pregrel | Active Comparator | pregrel is a generic brand name of clopidogrel |
|
| Aspirin+Plavix | Active Comparator | plavix is a original brand name of clopidogrel |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| aspirin + pregrel (Clopidogrel resinate) | Drug |
|
|
| Measure | Description | Time Frame |
|---|---|---|
| The percentage of P2Y12 receptor inhibition assessed by Ultegra rapid platelet function analyzer, (Baseline platelet reaction unit (PRU)- posttreatment PRU)/Baseline PRU * 100 (%)) | 1 month |
| Measure | Description | Time Frame |
|---|---|---|
| Adverse events after study medication | 1 month |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Ki-Bae Seung, MD, PhD | Seoul St. Mary's Hospital | Study Director |
| Chung-Hwan Gwak, MD, PhD | Gyeongsang National University Hospital | Study Director |
| Kwon-Sam Kim, MD,PhD | Kyung Hee University Hospital | Study Director |
| Soon-Jun Hong, MD,PhD | Korea University Anam Hospital | Study Director |
| Tae-Ho Park, MD,PhD | Dong-A medical center | Study Director |
| Sang-Hyun Kim, MD,PhD | Seoul Metropolitan Boramae Hospital | Study Director |
| Seung-Jea Tahk, MD,PhD | Ajou University Medical Center | Study Director |
| Seung-Jae Joo, MD,PhD | Jeju National University Hospital | Study Director |
| Young-Jin Choi, MD,PhD | Hallym University Medical Center | Study Director |
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| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 21816478 | Derived | Suh JW, Seung KB, Gwak CH, Kim KS, Hong SJ, Park TH, Kim SH, Choi YJ, Joo SJ, Tahk SJ, Kim HS. Comparison of antiplatelet effect and tolerability of clopidogrel resinate with clopidogrel bisulfate in patients with coronary heart disease (CHD) or CHD-equivalent risks: a phase IV, prospective, double-dummy, parallel-group, 4-week noninferiority trial. Clin Ther. 2011 Aug;33(8):1057-68. doi: 10.1016/j.clinthera.2011.07.001. Epub 2011 Aug 4. |
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| aspirin + placebo | Drug |
|
| aspirin + plavix (Clopidogrel bisulfate) | Drug |
|
|
| ID | Term |
|---|---|
| D003327 | Coronary Disease |
| ID | Term |
|---|---|
| D017202 | Myocardial Ischemia |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
| D014652 | Vascular Diseases |
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| ID | Term |
|---|---|
| D001241 | Aspirin |
| C528439 | clopidogrel resinate |
| D000077144 | Clopidogrel |
| ID | Term |
|---|---|
| D012459 | Salicylates |
| D062385 | Hydroxybenzoates |
| D010636 | Phenols |
| D001555 | Benzene Derivatives |
| D006841 | Hydrocarbons, Aromatic |
| D006844 | Hydrocarbons, Cyclic |
| D006838 | Hydrocarbons |
| D009930 | Organic Chemicals |
| D013988 | Ticlopidine |
| D058924 | Thienopyridines |
| D013876 | Thiophenes |
| D013457 | Sulfur Compounds |
| D011725 | Pyridines |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |
| D006574 | Heterocyclic Compounds, 2-Ring |
| D000072471 | Heterocyclic Compounds, Fused-Ring |
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