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| Name | Class |
|---|---|
| National Institutes of Health (NIH) | NIH |
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Asthma is a disease that affects more than 12% of Americans under the age of 18 for over 14 million missed school days per year, and is the number one cause of school absences in America. Elementary school children spend 6 to 10 hours a day in school, and most of that time is spent in one classroom. The goals of this project are to provide an understanding of exposure risk factors specific to the classroom. This is critical, because the classroom environment could potentially be considered as an effective target for prevention of inner-city asthma morbidity by reducing exposures to many symptomatic children through an intervention in the school classrooms.
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| Measure | Description | Time Frame |
|---|---|---|
| Maximum Symptom Days/14 Days | Largest value among the following: Number of days with wheezing, tightness in the chest, or cough Number of nights with disturbed sleep as a result of asthma Number of days on which the child had to slow down or discontinue play activities because of asthma | 14 days |
| Measure | Description | Time Frame |
|---|---|---|
| Days of Slowed Activity Due to Asthma | 12 months | |
| Days of Exercise-induced Symptoms | 12 months | |
| Days of Cough Without an Upper Respiratory Infection |
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Inclusion Criteria:
Exclusion Criteria:
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elementary school students with asthma
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Children's Hospital, Boston | Boston | Massachusetts | 02115 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 23176873 | Background | Phipatanakul W, Matsui E, Portnoy J, Williams PB, Barnes C, Kennedy K, Bernstein D, Blessing-Moore J, Cox L, Khan D, Lang D, Nicklas R, Oppenheimer J, Randolph C, Schuller D, Spector S, Tilles SA, Wallace D, Sublett J, Bernstein J, Grimes C, Miller JD, Seltzer J; Joint Task Force on Practice Parameters. Environmental assessment and exposure reduction of rodents: a practice parameter. Ann Allergy Asthma Immunol. 2012 Dec;109(6):375-87. doi: 10.1016/j.anai.2012.09.019. No abstract available. | |
| 23062384 |
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| ID | Title | Description |
|---|---|---|
| FG000 | Observational Cohort | students with asthma grades K-8 after the spring screening attending schools where permission for sampling obtained |
| Title | Milestones | Reasons Not Completed | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Overall Study |
|
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| ID | Title | Description |
|---|---|---|
| BG000 | Observational Cohort | students with asthma grades K-8 after the spring screening attending schools where permission for sampling obtained |
| Units | Counts |
|---|---|
| Participants |
|
| Title | Description | Population Description | Parameter Type | Dispersion Type | Unit of Measure | Calculate Percentage | Denominator Units Selected | Denominators | Classes |
|---|---|---|---|---|---|---|---|---|---|
| Age, Continuous | Mean |
| Type | Title | Description | Population Description | Reporting Status | Anticipated Posting Date | Parameter Type | Dispersion Type | Unit of Measure | Calculate Percentage | Time Frame | Units Analyzed | Denominator Units Selected | Arm/Group Information | Denominators | Classes | Analyses |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Secondary | Days of Slowed Activity Due to Asthma | Not Posted | 12 months | |||||||||||||
| Secondary | Days of Exercise-induced Symptoms | Not Posted | 12 months | |||||||||||||
1 year
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| ID | Title | Description | Deaths (Affected) | Deaths (At Risk) | Serious Events (Affected) | Serious Events (At Risk) | Other Events (Affected) | Other Events (At Risk) |
|---|---|---|---|---|---|---|---|---|
| EG000 | Observational Cohort | students with asthma grades K-8 after the spring screening attending schools where permission for sampling obtained |
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| Title | Organization | Phone | Extension | |
|---|---|---|---|---|
| Wanda Phipatanakul | Boston Children's Hospital | 617-355-6117 | wanda.phipatanakul@childrens.harvard.edu |
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| ID | Term |
|---|---|
| D001249 | Asthma |
| D006967 | Hypersensitivity |
| ID | Term |
|---|---|
| D001982 | Bronchial Diseases |
| D012140 | Respiratory Tract Diseases |
| D008173 | Lung Diseases, Obstructive |
| D008171 | Lung Diseases |
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| 12 months |
| Nights of Wakening Due to Asthma Symptoms | 12 months |
| Number of Hospitalizations | 12 months |
| Emergency Department Visits | 12 months |
| Unscheduled Physician/Health Care Visits | 12 months |
| Prednisone Bursts | 12 months |
| FEV1/FVC | 12 months |
| FEV1 Percent Predicted | 12 months |
| Percent Change in FEV1 After Short-acting Beta Agonist | 12 months |
| Exhaled Nitric Oxide Levels | 12 months |
| Background |
| Bartnikas LM, Sheehan WJ, Hoffman EB, Permaul P, Dioun AF, Friedlander J, Baxi SN, Schneider LC, Phipatanakul W. Predicting food challenge outcomes for baked milk: role of specific IgE and skin prick testing. Ann Allergy Asthma Immunol. 2012 Nov;109(5):309-313.e1. doi: 10.1016/j.anai.2012.07.026. Epub 2012 Aug 21. |
| 22742446 | Background | Rao DR, Gaffin JM, Baxi SN, Sheehan WJ, Hoffman EB, Phipatanakul W. The utility of forced expiratory flow between 25% and 75% of vital capacity in predicting childhood asthma morbidity and severity. J Asthma. 2012 Aug;49(6):586-92. doi: 10.3109/02770903.2012.690481. Epub 2012 Jun 28. |
| 21710109 | Background | Rao D, Phipatanakul W. Impact of environmental controls on childhood asthma. Curr Allergy Asthma Rep. 2011 Oct;11(5):414-20. doi: 10.1007/s11882-011-0206-7. |
| 22672325 | Result | Permaul P, Hoffman E, Fu C, Sheehan W, Baxi S, Gaffin J, Lane J, Bailey A, King E, Chapman M, Gold D, Phipatanakul W. Allergens in urban schools and homes of children with asthma. Pediatr Allergy Immunol. 2012 Sep;23(6):543-9. doi: 10.1111/j.1399-3038.2012.01327.x. Epub 2012 Jun 6. |
| 22626594 | Result | Sheehan WJ, Hoffman EB, Fu C, Baxi SN, Bailey A, King EM, Chapman MD, Lane JP, Gaffin JM, Permaul P, Gold DR, Phipatanakul W. Endotoxin exposure in inner-city schools and homes of children with asthma. Ann Allergy Asthma Immunol. 2012 Jun;108(6):418-22. doi: 10.1016/j.anai.2012.04.003. Epub 2012 Apr 26. |
| 22010992 | Result | Phipatanakul W, Bailey A, Hoffman EB, Sheehan WJ, Lane JP, Baxi S, Rao D, Permaul P, Gaffin JM, Rogers CA, Muilenberg ML, Gold DR. The school inner-city asthma study: design, methods, and lessons learned. J Asthma. 2011 Dec;48(10):1007-14. doi: 10.3109/02770903.2011.624235. Epub 2011 Oct 20. |
| 21962100 | Result | Baxi SN, Sheehan WJ, Gaffin JM, Yodying J, Panupattanapong S, Lane JP, Fu C, Hoffman EB, Gold DR, Phipatanakul W. Agreement between parent and student responses to an asthma and allergy questionnaire in a diverse, inner-city elementary school population. Ann Allergy Asthma Immunol. 2011 Oct;107(4):371-3. doi: 10.1016/j.anai.2011.08.007. No abstract available. |
| 31557500 | Derived | Hauptman M, Gaffin JM, Petty CR, Sheehan WJ, Lai PS, Coull B, Gold DR, Phipatanakul W. Proximity to major roadways and asthma symptoms in the School Inner-City Asthma Study. J Allergy Clin Immunol. 2020 Jan;145(1):119-126.e4. doi: 10.1016/j.jaci.2019.08.038. Epub 2019 Sep 23. |
| 30904580 | Derived | Baxi SN, Sheehan WJ, Sordillo JE, Muilenberg ML, Rogers CA, Gaffin JM, Permaul P, Lai PS, Louisias M, Petty CR, Fu C, Gold DR, Phipatanakul W. Association between fungal spore exposure in inner-city schools and asthma morbidity. Ann Allergy Asthma Immunol. 2019 Jun;122(6):610-615.e1. doi: 10.1016/j.anai.2019.03.011. Epub 2019 Mar 20. |
| 26087201 | Derived | Lai PS, Sheehan WJ, Gaffin JM, Petty CR, Coull BA, Gold DR, Phipatanakul W. School Endotoxin Exposure and Asthma Morbidity in Inner-city Children. Chest. 2015 Nov;148(5):1251-1258. doi: 10.1378/chest.15-0098. |
| years |
|
| Sex: Female, Male | Count of Participants | Participants |
|
| Region of Enrollment | Students with asthma from participating schools | Number | participants |
|
| Secondary |
| Days of Cough Without an Upper Respiratory Infection |
| Not Posted |
| 12 months |
| Secondary | Nights of Wakening Due to Asthma Symptoms | Not Posted | 12 months |
| Secondary | Number of Hospitalizations | Not Posted | 12 months |
| Secondary | Emergency Department Visits | Not Posted | 12 months |
| Secondary | Emergency Department Visits | Not Posted | 12 months |
| Secondary | Unscheduled Physician/Health Care Visits | Not Posted | 12 months |
| Secondary | Prednisone Bursts | Not Posted | 12 months |
| Secondary | FEV1/FVC | Not Posted | 12 months |
| Secondary | FEV1 Percent Predicted | Not Posted | 12 months |
| Secondary | Percent Change in FEV1 After Short-acting Beta Agonist | Not Posted | 12 months |
| Secondary | Exhaled Nitric Oxide Levels | Not Posted | 12 months |
| Primary | Maximum Symptom Days/14 Days | Largest value among the following: Number of days with wheezing, tightness in the chest, or cough Number of nights with disturbed sleep as a result of asthma Number of days on which the child had to slow down or discontinue play activities because of asthma | Those with appropriate follow up and school/home allergen exposure data and allergy sensitization data | Posted | Mean | Standard Deviation | days | 14 days |
|
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| 0 |
| 351 |
| 0 |
| 351 |
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| D012130 |
| Respiratory Hypersensitivity |
| D006969 | Hypersensitivity, Immediate |
| D007154 | Immune System Diseases |