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This study plan to study the association between household health behavior (cleaning habits) and children's asthma. In addition, reconfirm the health effects of indoor environmental exposure to phthalates plasticizers, mite, fungi, and bacteria, and cockroaches on children's asthma. Thus, the investigators can provide a non-pharmacological intervention to reduce the disease burden of children's asthma and allergic diseases.
The investigators plan to invite 80 children, aged 7-12 years-old who have physician-diagnosed asthma, and another age- and gender-matched children without asthma to join our study. First, obtaining clinical data of disease status, and ask participants to fill out questionnaires after recruiting. Second, participants have to record body temperature, peak expiratory flow, heart rate, finger O2 saturation percentage, asthma attack frequency continuously by care-giver every day. Third, the investigators will perform indoor environmental assessments in the subject's house, including indoor air quality, dust samples, culture for fungi and bacteria, and cockroaches. The investigators will also count the dust mites and measure phthalates concentration in every dust sample.
Then, health behavior intervention for one month will be provided to every participant. The investigators will teach children's guardians (care-giver) how to change the health behaviors to clean indoor environment, including the health behaviors in bedroom, kitchen room, restroom, refrigerator, washing machine, and incense burning hall. After 1 months, the investigators will investigate whether changing health behavior affects the exposure of phthalates, dust mites, fungi, bacteria, and cockroaches, and evaluate the effects of health behavior intervention on the clinical status of children's asthma. Children's asthma severity assessment will be recorded by ACT and also by symptomatology every day. Household health behaviors (cleaning habits) questionnaires also will be completed per week and continuously for 4 weeks.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Health behaviors | Other | Health behavior intervention for one month will be provided to every participant. We will teach children's guardians (care-giver) how to change the health behaviors to clean indoor environment, including the health behaviors in bedroom, kitchen room, restroom, refrigerator, washing machine, and incense burning hall. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| change the health behaviors to clean indoor environment | Other | Sheets and all covers should be wash weekly. Clean indoor environment with a vacuum cleaner twice a week |
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| Measure | Description | Time Frame |
|---|---|---|
| Peak expiratory flow changes | Using peak flow meter to monitor the participant's peak expiratory flow values in the morning and evening to effectively evaluate subject's asthma status. | one month |
| fractional concentration of exhaled nitric oxide | Before and after the intervention, test for the levels of fractional exhaled nitric oxide in the hospital to evaluate the condition of airway inflammation. | one month |
| Pulmonary function test (FVC) | Before and after the intervention, test for the volumes of the forced vital capacity (FVC) in the hospital as an indicator of asthma status. | one month |
| Pulmonary function test (FEV1) | Before and after the intervention, test for the volumes of the forced expiratory volume in one second (FEV1) in the hospital as an indicator of asthma status. | one month |
| Pulmonary function test (FEV1/FVC ratio) | Before and after the intervention, test for the FEV1/FVC ratio in the hospital as an indicator of asthma status. | one month |
| Symptomatology (cough) | Asthma symptom is recorded daily by caregivers. | one month |
| Symptomatology (wheezing) | Asthma symptom is recorded daily by caregivers. | one month |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Ta-Chen Su, PhD | Contact | +886223123456 | 66719 | lab.of.su@gmail.com |
| Name | Affiliation | Role |
|---|---|---|
| Ta-Chen Su, PhD | National Taiwan University Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| National Taiwan University Hospital | Recruiting | Taipei | Chung-Shan | 10002 | Taiwan |
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| Symptomatology (chest tightness) | Asthma symptom is recorded daily by caregivers. | one month |
| dust mites allergen concentrations | Before and after the intervention, allergen concentrations will be sampled in a fixed area in the subject's bedroom, and dust mites' antibody will be analyzed in the laboratory. | one month |
| phthalates concentrations | Sampling in a fixed area in the subject's bedroom, and phthalates concentration will be analyzed in the laboratory. | one month |
| cockroach numbers | Before and after the intervention, count the numbers of cockroach will be sampled for every week, in a fixed area in the subject's bedroom. | one month |