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The aim of the study is to investigate whether exercise improves cognitive and motor functions in Parkinson's disease. To test this hypothesis, the researchers study general brain functions in subjects with PD during a 6-months exercise program.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| stationary bike exercise | Experimental | 6 months of exercise (60% of anaerobic threshold) |
|
| aerobic | Placebo Comparator | 6 months of exercise <30% anaerobic threshold |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| stationary bike exercise | Behavioral |
| ||
| aerobic |
| Measure | Description | Time Frame |
|---|---|---|
| UPDRS motor score | Prior to intervention and after 6 months of intervention |
| Measure | Description | Time Frame |
|---|---|---|
| Functional/Structural brain changes | Prior to intervention and after 6 months of intervention | |
| Plasma biomarkers | Prior to intervention and after 6 months of intervention | |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Agnes Flöel, MD | Charite University, Berlin, Germany | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Neurology, Charité Universitätsmedizin Berlin | Berlin | State of Berlin | 10117 | Germany |
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| ID | Term |
|---|---|
| D010300 | Parkinson Disease |
| ID | Term |
|---|---|
| D020734 | Parkinsonian Disorders |
| D001480 | Basal Ganglia Diseases |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
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|
| Cognitive Function based on neuropsychological test-performance |
| Prior to intervention and after 6 months of intervention |
| D009422 | Nervous System Diseases |
| D009069 | Movement Disorders |
| D000080874 | Synucleinopathies |
| D019636 | Neurodegenerative Diseases |