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| ID | Type | Description | Link |
|---|---|---|---|
| 120000MM | Other Grant/Funding Number | Oslo University Hospital |
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| Name | Class |
|---|---|
| University of Oslo | OTHER |
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Low Body Mass Index (BMI) is a risk factor for hip fracture, but it is unknown if it is the low BMI per se that increases risk of hip fracture or if specific micro-nutrients contribute. The investigators want to elucidate this aspect in a case control study studying micronutrients in serum and bone turnover markers of hip fracture patients compared with controls of the same age.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Cases | Hip fracture patients participating in a randomised controlled trial (RCT) of orthogeriatric care (ClinicalTrials.gov NCT01009268) | ||
| Controls | A group of voluntary elderly persons without a history of hip fracture, recruited specifically for this purpose |
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| Measure | Description | Time Frame |
|---|---|---|
| micronutrient association with increased risk of hip fracture | Blood was drawn for micronutrient analysis in hip fracture patients and in controls | At admission |
| Measure | Description | Time Frame |
|---|---|---|
| Are micronutrients related to bone turnover markers | Blood was drawn for bone turnover analysis. Correlation analysis with micronutrients was performed | At admission |
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Inclusion Criteria:
Cases are admitted acutely for a femoral neck fracture, a trochanteric or a subtrochanteric femoral fracture.
Exclusion Criteria:
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Cases: The first 116 patients of an ongoing RCT were included consecutively and examined by blood samples pre operatively for nutrition and hormone analysis. The catchment area for the cases was the city of Oslo, Norway.
A control group, at the same age with no history of hip fracture, was drawn at random from inhabitants aged 60 - 100 years (median age 82 years) at the census files of Oslo in 2005.
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| Name | Affiliation | Role |
|---|---|---|
| Morten Mowe, PhD | Oslo University Hospital | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Oslo, Institute of Clinical Medicine | Oslo | 0424 | Norway |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 30661701 | Derived | Torbergsen AC, Watne LO, Frihagen F, Wyller TB, Mowe M. Effects of nutritional intervention upon bone turnover in elderly hip fracture patients. Randomized controlled trial. Clin Nutr ESPEN. 2019 Feb;29:52-58. doi: 10.1016/j.clnesp.2017.11.012. Epub 2018 Oct 30. | |
| 26795217 | Derived | Torbergsen AC, Watne LO, Wyller TB, Frihagen F, Stromsoe K, Bohmer T, Mowe M. Micronutrients and the risk of hip fracture: Case-control study. Clin Nutr. 2017 Apr;36(2):438-443. doi: 10.1016/j.clnu.2015.12.014. Epub 2015 Dec 23. |
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| ID | Term |
|---|---|
| D006620 | Hip Fractures |
| ID | Term |
|---|---|
| D005264 | Femoral Fractures |
| D050723 | Fractures, Bone |
| D014947 | Wounds and Injuries |
| D025981 | Hip Injuries |
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For vitamin and hormone analysis serum was collected For some vitamin analysis EDTA blood was collected For RNA analysis fullblood was collected
| D007869 |
| Leg Injuries |