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| ID | Type | Description | Link |
|---|---|---|---|
| ZonMw 80-007022-98-07510 |
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| Name | Class |
|---|---|
| ZonMw: The Netherlands Organisation for Health Research and Development | OTHER |
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Hip fractures are highly prevalent and are expected to increase due to the ageing population. Malnutrition is often present in these patients and is associated with prolonged convalescence, lower mobility, lower mental function, lower quality of life and higher complication rate. Nutritional intervention starting soon after hospital admission might reduce complication rate and total length-of-stay by improving nutritional and functional status. Research questions are:
Patients randomized to the intervention group will receive oral nutritional supplements (protein and energy enriched) and regular dietetic counselling during hospitalisation and after discharge at patients' homes for 3 months. Patients in the control group will receive usual nurse and dietetic care. Outcome measurements will be taken at baseline, 3 months and 6 months after inclusion.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| C | No Intervention | Usual nurse and dietetic care | |
| I | Experimental | Intensive nutritional support composed of oral dietary supplement combined with dietetic counselling. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Cubitan | Dietary Supplement | 400 ml/d |
|
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| Measure | Description | Time Frame |
|---|---|---|
| Total length of hospital stay and rehabilitation clinics | baseline, 3 months and 6 months after inclusion |
| Measure | Description | Time Frame |
|---|---|---|
| Nutritional status, hip functionality, physical disability, fatigue, quality of life. | baseline, 3 months and 6 months after inclusion | |
| Cost questionnaire, informal care questionnaire. | baseline, 3 months and 6 months after inclusion |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| P C Dagnelie, PhD | Maastricht University - Faculty of Health Medicine and Life Sciences - Department of Epidemiologie | Principal Investigator |
| P LM Reijven, PhD | Maastricht University Hospital - Department of Dietetics & Maastricht University - Faculty of Health Medicine and Life Sciences - Department of Epidemiology | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Atrium MC | Heerlen | 6419 PC | Netherlands | |||
| Maastricht University Hospital |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 30204859 | Derived | Wyers CE, Reijven PLM, Breedveld-Peters JJL, Denissen KFM, Schotanus MGM, van Dongen MCJM, Eussen SJPM, Heyligers IC, van den Brandt PA, Willems PC, van Helden S, Dagnelie PC. Efficacy of Nutritional Intervention in Elderly After Hip Fracture: A Multicenter Randomized Controlled Trial. J Gerontol A Biol Sci Med Sci. 2018 Sep 11;73(10):1429-1437. doi: 10.1093/gerona/gly030. | |
| 22035956 |
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| ID | Term |
|---|---|
| D006620 | Hip Fractures |
| D044342 | Malnutrition |
| D010024 | Osteoporosis |
| ID | Term |
|---|---|
| D005264 | Femoral Fractures |
| D050723 | Fractures, Bone |
| D014947 | Wounds and Injuries |
| D025981 | Hip Injuries |
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| Rate of complications | baseline, 3 months and 6 months after inclusion |
| Maastricht |
| 6229 HA |
| Netherlands |
| Maaslandziekenhuis | Sittard | 6131 BK | Netherlands |
| Derived |
| Breedveld-Peters JJ, Reijven PL, Wyers CE, van Helden S, Arts JJ, Meesters B, Prins MH, van der Weijden T, Dagnelie PC. Integrated nutritional intervention in the elderly after hip fracture. A process evaluation. Clin Nutr. 2012 Apr;31(2):199-205. doi: 10.1016/j.clnu.2011.10.004. Epub 2011 Oct 28. |
| 20423469 | Derived | Wyers CE, Breedveld-Peters JJ, Reijven PL, van Helden S, Guldemond NA, Severens JL, Verburg AD, Meesters B, van Rhijn LW, Dagnelie PC. Efficacy and cost-effectiveness of nutritional intervention in elderly after hip fracture: design of a randomized controlled trial. BMC Public Health. 2010 Apr 27;10:212. doi: 10.1186/1471-2458-10-212. |
| D007869 |
| Leg Injuries |
| D009748 | Nutrition Disorders |
| D009750 | Nutritional and Metabolic Diseases |
| D001851 | Bone Diseases, Metabolic |
| D001847 | Bone Diseases |
| D009140 | Musculoskeletal Diseases |
| D008659 | Metabolic Diseases |