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| Name | Class |
|---|---|
| Health Service Executive, Ireland | OTHER |
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Hip fracture is a big health concern in older adults, and can lead to increased risk of death, reduced level of independence & mobility, reduced quality of life, and higher likelihood of admission to nursing homes. Frailty is a medical condition associated with ageing that results in a reduced ability to do daily tasks. A frail older adult is also less able to recover well from conditions that may affect their wellbeing (for example, infections, falls resulting in injuries or hospital admissions). Frailty is common in older adults with hip fractures.
There has been increasing research showing that frailty can be slowed down and improved by a combination of nutritional supplementation and exercise. However, most of the research in this area has been in frail older adults living at home or in nursing homes. The exercise or nutritional programs in these studies tend to be carried out over weeks or months. There are very few studies looking at older adults in hospital and how exercise and nutrition help with frailty over shorter periods of time, even more so in patients who have sustained an injury.
There is, however, very little research in hospital based frailty programs in older patients who have suffered major trauma. It is well known that standing up and starting to walk soon after a hip fracture improves time to recovery, reduces hospital length of stay and death. Hence, physiotherapy on the first day after hip fracture surgery is now recommended. However, there needs to be more research to aid in developing physiotherapy and exercise programs that are safe and doable in the care of hip fracture patients despite limited resources in our healthcare system.
Similarly, although malnutrition is common in frail older adults with hip fractures, the benefits of nutritional supplementation in these patients is not fully understood. It is known that having a hip fracture puts a person at risk of muscle breakdown and increasing protein intake is recommended to help reduce this risk. Research on exercise and nutrition based frailty programs specific to hip fracture patients is strongly needed, specifically the development of that are doable and safe in the hospital setting that can help improve outcomes in hip fracture patients after surgery.
The investigators believe that a multicomponent exercise and nutrition based frailty program will be safe, doable and acceptable in frail older adults after hip fracture surgery.
Hip fractures are often the result of falls in the frail older population and result in subsequent poor quality of life and mortality.Over a third of older adults die in the first year after having sustained a hip fracture, suggesting that this may be a result of frailty and the beginning of a decline towards end of life. The incidence of patients presenting with hip fractures is predicted to rise to 11.9% in 2030 compared to 2010. Hip fracture care contributes to a significant burden towards healthcare systems, costing approximately £25,000 per episode and almost £1 billion per annum in the United Kingdom. This likely stems from the likelihood of its association with longer hospital length of stays, multimorbidity and readmissions. Frailty, an age related impairment of physical reserves and resilience, is common in hip fracture patients, and plays a significant role in determining outcomes in this cohort.
Current recommendations suggest early mobilisation post hip fracture to facilitate return to pre-fracture mobility and independence. Intensive in-hospital rehabilitation of post hip fracture patients have been shown to impart greater improvements in physical function and activities of daily living. Hence, physiotherapy on the first day postoperatively is now a recognized quality standard. To supplement this, it is recommended that rehabilitation be provided by multidisciplinary healthcare teams to maximize potential for return to pre-fracture level of function.
The prevalence of malnutrition in hip fracture patients is often high. The management of this problem, particularly in hip fracture patients is challenging. Reduced oral intake in older inpatients are often multifactorial. Studies involving monomodal nutritional interventions in hip fracture patients have shown mixed results. It has been shown that early nutritional intervention led by dieticians was associated with lower prevalence of malnutrition and incidence of pressure ulcers. There was also an association with reduced subacute length of stay. Another study demonstrated that combined nutritional counselling and intensive nutritional intervention led by a dietician reduced malnutrition and improved dietary intake, but only for the duration of the intervention. However, a Cochrane review concluded that nutritional supplementation in the aftercare of hip fracture patients had unclear benefit on outcomes and more randomised trials with robust methodology are required.
There is now an established body of evidence that frailty is modifiable through a combination of nutrition and exercise. However, most of the studies to date have examined interventions delivered over longer periods (e.g. months); and in the community setting. There is however, emerging evidence of in-hospital multicomponent interventions targeting physical and non-physical components of frailty. A recent study showed that a multicomponent intervention in frail and pre-frail adults with cardiovascular disease was safe and feasible in the acute setting. This encompassed additional encouragement to mobilize between usual physiotherapy visits and eat during meals. Additional cognitive stimulation activities and screening and addressing iron deficiency anaemia were also performed bi-daily. It has been shown that an in-hospital multidomain intervention that included nutrition and frailty education and advice, an exercise intervention and cognitive stimulation activities improved frailty and activities of daily living at time of discharge as well as reduced length of stay and subsequent healthcare utilisation.
There is still a relative paucity of research in frailty interventions in older patients who sustained major trauma, and in particular in multi-modal interventions. Studies to date in this population have explored interventions aiming to enhance recovery post-hip fracture for frail patients, however specifically looked at mono-modal interventions, included outpatient interventions in the analyses or only addressed specific components of frailty separately such as cognitive impairment or sarcopenia in the evaluation of rehabilitation strategies in this cohort.
The objective of this study is to assess the feasibility of this intervention in the acute postoperative aftercare of frail older inpatients with hip fracture.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Usual Care | Active Comparator | This arm will assess all aspects of usual postoperative hip fracture care which will include multidisciplinary team assessment which include physiotherapists, occupational therapists, dieticians as well as specialist nurses and doctors working as part of the orthogeriatric team (falls and bone health assessment). They will receive daily physiotherapy training starting on the first postoperative day which will include mobility, balance, strength and gait training. This group will also receive additional protein supplementation in the form of a nutritional supplement twice daily as part of usual postoperative hip fracture care. All patients will undergo baseline assessments including assessment of level of frailty, pre-fracture level of mobility & function, postoperative mobility, nutritional status/ screening, grip strength and level of pain. All patients will be asked to maintain a three-day food diary to monitor their protein intake. |
|
| Exercise and Nutritional Intervention | Experimental | This arm will include and exercise and nutritional intervention in addition to usual postoperative hip fracture care. The exercise program will be delivered 3-5 times per week, each session lasting between 20-30 minutes depending on patient tolerance. The program will be progressed gradually between sessions and be guided by patient tolerance. The program will involve bed/ chair-based aerobic and resistance training (using an arm crank ergometer, resistance bands and ankle weights). The program will be delivered over the entire length of a patient's hospital stay up to a duration of 6 weeks for prolonged stays. The nutritional intervention will take the form of a protein fortified evening snack administered by nursing staff (additional 20g of protein). All patients will undergo baseline assessments including assessment of level of frailty, pre-fracture level of mobility & function, postoperative mobility, nutritional status/ screening, grip strength and level of pain. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Exercise Intervention | Behavioral | This arm will include and exercise and nutritional intervention in addition to usual postoperative hip fracture care. The exercise program will be delivered 3-5 times per week, each session lasting between 20-30 minutes depending on patient tolerance. The program will be progressed gradually between sessions and be guided by patient tolerance. The program will involve bed/ chair-based aerobic and resistance training (using an arm crank ergometer, resistance bands and ankle weights). The program will be delivered over the entire length of a patient's hospital stay up to a duration of 6 weeks for prolonged stays. All patients will undergo baseline assessments including assessment of level of frailty, pre-fracture level of mobility & function, postoperative mobility, nutritional status/ screening, grip strength and level of pain. |
| Measure | Description | Time Frame |
|---|---|---|
| Eligibility Rate | Patients eligible for inclusion/ total number of admissions | Through study completion, an average of 6 months |
| Recruitment Rate | Recruited patients/ Patients eligible for inclusion | Through study completion, an average of 6 months |
| Number of drop outs | Number of participant dropouts after recruitment into study | Through study completion, an average fo 6 months |
| Number of intervention related adverse events | Musculoskeletal injury/ pain, nausea, vomiting, aspiration, constipation etc. | Through study completion, an average of 6 months |
| Compliance to prescribed duration of exercise sessions | Percentage of sessions achieving 25 minutes of training | Through completion of intervention, an average of 3 weeks up to a maximum of 6 weeks |
| Patient Acceptability of Intervention | Survey utilising open ended questions and 5 point Likert Scales (Strongly Agree, Agree, Neither Agree nor Disagree, Disagree, Strongly Disagree) will be used to evaluate patient satisfaction of the intervention. | Through study completion, an average of 6 months |
| Nursing staff acceptability of intervention delivery | Survey utilising open ended questions and 5 point Likert Scales (Strongly Agree, Agree, Neither Agree nor Disagree, Disagree, Strongly Disagree) will be used to evaluate patient satisfaction of the intervention. |
| Measure | Description | Time Frame |
|---|---|---|
| Cumulative Ambulation Score (CAS) | Daily score will be 0-6, higher score indicates higher level of independence. Cumulative score over 3 days results in a score of 0-18. | At baseline and within 48 hours of discharge from hospital |
| Grip strength (Dominant hand) |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Arveen Jeyaseelan, MB BCh BAO | Contact | +35351847557 | arveenjeyaseelan20@rcsi.com |
| Name | Affiliation | Role |
|---|---|---|
| Niamh O'Regan, MB BCh BAO, B Med Sci, FRCPI | University Hospital Waterford | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University Hospital Waterford | Waterford | Waterford | X91ER8E | Ireland |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 27898998 | Background | Avenell A, Smith TO, Curtain JP, Mak JC, Myint PK. Nutritional supplementation for hip fracture aftercare in older people. Cochrane Database Syst Rev. 2016 Nov 30;11(11):CD001880. doi: 10.1002/14651858.CD001880.pub6. | |
| 21413492 | Background | Saunders J, Smith T. Malnutrition: causes and consequences. Clin Med (Lond). 2010 Dec;10(6):624-7. doi: 10.7861/clinmedicine.10-6-624. No abstract available. |
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This will be stored in secure storage for the required duration after completion of study as specified by Good Clinical Practice, after which data will be destroyed.
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Study will first be conducted in usual care group and subsequent progress to intervention group
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|
| Usual Care | Other | This arm will assess all aspects of usual postoperative hip fracture care which will include multidisciplinary team assessment which include physiotherapists, occupational therapists, dieticians as well as specialist nurses and doctors working as part of the orthogeriatric team (falls and bone health assessment). They will receive daily physiotherapy training starting on the first postoperative day which will include mobility, balance, strength and gait training. This group will also receive additional protein supplementation in the form of a nutritional supplement twice daily as part of usual postoperative hip fracture care. All patients will undergo baseline assessments including assessment of level of frailty, pre-fracture level of mobility & function, postoperative mobility, nutritional status/ screening, grip strength and level of pain. All patients will be asked to maintain a three-day food diary to monitor their protein intake. |
|
|
| Nutritional Intervention | Dietary Supplement | The nutritional intervention will take the form of a protein fortified evening snack administered by nursing staff (additional 20g of protein). |
|
|
| Through study completion, an average of 6 months |
| Compliance with prescribed intensity | Percentage of sessions completed at Borg Scale score 4-6 | Through completion of intervention, an average of 3 weeks up to a maximum of 6 weeks |
| Attendance rate | Number of completed sessions/ number of planned sessions | Through completion of intervention, an average of 3 weeks up to a maximum of 6 weeks |
| Compliance rate to prescribed nutritional intervention | Number of supplements taken/ number prescribed | Through completion of intervention, an average of 3 weeks up to a maximum of 6 weeks |
Grip strength will be assessed using a handheld dynamometer. Measured in units of kg. |
| At baseline and within 48 hours of discharge from hospital |
| Verbal Rating Scale for Pain (VRS) | Visual scale of 0-3, higher scores indicating more severe pain. | At baseline and within 48 hours of discharge from hospital |
| Functional Independence Measure (FIM) | This tool measures activities of daily living, scores range from 18-126, higher scores indicates higher level of independence. | At baseline and within 48 hours of discharge from hospital |
| Barthel Index | This tool measures activities of daily living, scored 0-20, higher scores indicates a higher level of independence | At baseline and within 48 hours of discharge from hospital |
| Length of Stay (LOS) in hospital | acute hospital stay + super-spell (LOS in acute rehabilitation units) | Through intervention completion, an average of 3 weeks up to a maximum of 6 weeks for prolonged stays |
| Discharge Destination | Discharge destination from hospital will be recorded | Through intervention completion, an average of 3 weeks up to a maximum of 6 weeks for prolonged stays |
| Health related quality of life (HRQoL) | - Using EuroQol 5-dimension 5-level (EQ-5D-5L) scale. Assesses mobility, self care, activities of daily living, pain, anxiety domains as well as general perception of health. Each dimension on the scale has five response options ranging from no problem to severe problems. The scale also consists of a visual analogue scale, higher values indicate better quality of life. | At baseline and 30 days post discharge |
| Upright and Sedentary Events | Measured using ActivPal Accelerometer | Throughout inpatient stay, average of 3 weeks up to a maximum of 6 weeks |
| Depression | Screened for using Geriatric Depression Scale (GDS). Screens for depression. Maximum score of 15 points. A score of 5 points or above indicates probable depression. | At baseline and within 48 hours of discharge from hospital |
| Fear of Falling | Measured Using the Falls Efficacy Scale- International (FES-I). Scored between 16-64, higher scores indicates increased concern for falling. | At baseline and within 48 hours of discharge from hospital |
| 29710860 | Background | Malafarina V, Reginster JY, Cabrerizo S, Bruyere O, Kanis JA, Martinez JA, Zulet MA. Nutritional Status and Nutritional Treatment Are Related to Outcomes and Mortality in Older Adults with Hip Fracture. Nutrients. 2018 Apr 30;10(5):555. doi: 10.3390/nu10050555. |
| Background | Audit NOoC. Irish Hip Fracture Database National Report 2023. 2024. |
| 21693526 | Background | Ftouh S, Morga A, Swift C; Guideline Development Group. Management of hip fracture in adults: summary of NICE guidance. BMJ. 2011 Jun 21;342:d3304. doi: 10.1136/bmj.d3304. No abstract available. |
| 36817328 | Background | Oberstar JS, Bakker CJ, Sorich M, McCarthy T. What Postoperative Nutritional Interventions Lead to Better Outcomes in Fragility Hip Fractures? A Systematic Review. Geriatr Orthop Surg Rehabil. 2023 Feb 15;14:21514593231155828. doi: 10.1177/21514593231155828. eCollection 2023. |
| 37231406 | Background | Phang JK, Lim ZY, Yee WQ, Tan CYF, Kwan YH, Low LL. Post-surgery interventions for hip fracture: a systematic review of randomized controlled trials. BMC Musculoskelet Disord. 2023 May 25;24(1):417. doi: 10.1186/s12891-023-06512-9. |
| 35969624 | Background | Cadel L, Kuluski K, Wodchis WP, Thavorn K, Guilcher SJT. Rehabilitation interventions for persons with hip fracture and cognitive impairment: A scoping review. PLoS One. 2022 Aug 15;17(8):e0273038. doi: 10.1371/journal.pone.0273038. eCollection 2022. |
| 32993140 | Background | Avola M, Mangano GRA, Testa G, Mangano S, Vescio A, Pavone V, Vecchio M. Rehabilitation Strategies for Patients with Femoral Neck Fractures in Sarcopenia: A Narrative Review. J Clin Med. 2020 Sep 26;9(10):3115. doi: 10.3390/jcm9103115. |
| 36810176 | Background | Halter M, Jarman H, Moss P, Kulnik ST, Baramova D, Gavalova L, Cole E, Crouch R, Baxter M. Configurations and outcomes of acute hospital care for frail and older patients with moderate to major trauma: a systematic review. BMJ Open. 2023 Feb 21;13(2):e066329. doi: 10.1136/bmjopen-2022-066329. |
| 37357324 | Background | Wang YC, Liang CK, Chou MH, Chiu CF, Lin HC, Hsu YH, Liao MC, Yin CH, Chou MY, Lin YT. The Effectiveness of Frailty Intervention for Older Patients with Frailty during Hospitalization. J Nutr Health Aging. 2023;27(6):413-420. doi: 10.1007/s12603-023-1924-y. |
| 28064173 | Background | Puts MTE, Toubasi S, Andrew MK, Ashe MC, Ploeg J, Atkinson E, Ayala AP, Roy A, Rodriguez Monforte M, Bergman H, McGilton K. Interventions to prevent or reduce the level of frailty in community-dwelling older adults: a scoping review of the literature and international policies. Age Ageing. 2017 May 1;46(3):383-392. doi: 10.1093/ageing/afw247. |
| 28579766 | Background | Dedeyne L, Deschodt M, Verschueren S, Tournoy J, Gielen E. Effects of multi-domain interventions in (pre)frail elderly on frailty, functional, and cognitive status: a systematic review. Clin Interv Aging. 2017 May 24;12:873-896. doi: 10.2147/CIA.S130794. eCollection 2017. |
| 31291884 | Background | Kidd T, Mold F, Jones C, Ream E, Grosvenor W, Sund-Levander M, Tingstrom P, Carey N. What are the most effective interventions to improve physical performance in pre-frail and frail adults? A systematic review of randomised control trials. BMC Geriatr. 2019 Jul 11;19(1):184. doi: 10.1186/s12877-019-1196-x. |
| 30510094 | Background | Travers J, Romero-Ortuno R, Bailey J, Cooney MT. Delaying and reversing frailty: a systematic review of primary care interventions. Br J Gen Pract. 2019 Jan;69(678):e61-e69. doi: 10.3399/bjgp18X700241. Epub 2018 Dec 3. |
| 28183809 | Background | Gardner B, Jovicic A, Belk C, Kharicha K, Iliffe S, Manthorpe J, Goodman C, Drennan VM, Walters K. Specifying the content of home-based health behaviour change interventions for older people with frailty or at risk of frailty: an exploratory systematic review. BMJ Open. 2017 Feb 9;7(2):e014127. doi: 10.1136/bmjopen-2016-014127. |
| 30176345 | Background | Nascimento CM, Ingles M, Salvador-Pascual A, Cominetti MR, Gomez-Cabrera MC, Vina J. Sarcopenia, frailty and their prevention by exercise. Free Radic Biol Med. 2019 Feb 20;132:42-49. doi: 10.1016/j.freeradbiomed.2018.08.035. Epub 2018 Aug 31. |
| 38905251 | Background | Dong X, Zhang X, Hu F, Yang S, Hong Z, Geng Q. Association of frailty with adverse outcomes in surgically treated geriatric patients with hip fracture: A meta-analysis and trial sequential analysis. PLoS One. 2024 Jun 21;19(6):e0305706. doi: 10.1371/journal.pone.0305706. eCollection 2024. |
| 35844855 | Background | Song Y, Wu Z, Huo H, Zhao P. The Impact of Frailty on Adverse Outcomes in Geriatric Hip Fracture Patients: A Systematic Review and Meta-Analysis. Front Public Health. 2022 Jun 30;10:890652. doi: 10.3389/fpubh.2022.890652. eCollection 2022. |
| 36117728 | Background | Forssten MP, Cao Y, Trivedi DJ, Ekestubbe L, Borg T, Bass GA, Mohammad Ismail A, Mohseni S. Developing and validating a scoring system for measuring frailty in patients with hip fracture: a novel model for predicting short-term postoperative mortality. Trauma Surg Acute Care Open. 2022 Sep 13;7(1):e000962. doi: 10.1136/tsaco-2022-000962. eCollection 2022. |
| 25611424 | Background | Pollock FH, Bethea A, Samanta D, Modak A, Maurer JP, Chumbe JT. Readmission within 30 days of discharge after hip fracture care. Orthopedics. 2015 Jan;38(1):e7-13. doi: 10.3928/01477447-20150105-53. |
| 20039864 | Background | White SM, Griffiths R, Holloway J, Shannon A. Anaesthesia for proximal femoral fracture in the UK: first report from the NHS Hip Fracture Anaesthesia Network. Anaesthesia. 2010 Mar;65(3):243-8. doi: 10.1111/j.1365-2044.2009.06208.x. Epub 2009 Dec 18. |
| Background | Maxwell L, White S. Anaesthetic management of patients with hip fractures: an update. Continuing Education in Anaesthesia, Critical Care & Pain. 2013;13(5):179-83. |
| 26286626 | Background | Leal J, Gray AM, Prieto-Alhambra D, Arden NK, Cooper C, Javaid MK, Judge A; REFReSH study group. Impact of hip fracture on hospital care costs: a population-based study. Osteoporos Int. 2016 Feb;27(2):549-58. doi: 10.1007/s00198-015-3277-9. Epub 2015 Aug 19. |
| 28748387 | Background | Williamson S, Landeiro F, McConnell T, Fulford-Smith L, Javaid MK, Judge A, Leal J. Costs of fragility hip fractures globally: a systematic review and meta-regression analysis. Osteoporos Int. 2017 Oct;28(10):2791-2800. doi: 10.1007/s00198-017-4153-6. Epub 2017 Jul 26. |
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| 34579060 | Background | Han CY, Crotty M, Thomas S, Cameron ID, Whitehead C, Kurrle S, Mackintosh S, Miller M. Effect of Individual Nutrition Therapy and Exercise Regime on Gait Speed, Physical Function, Strength and Balance, Body Composition, Energy and Protein, in Injured, Vulnerable Elderly: A Multisite Randomized Controlled Trial (INTERACTIVE). Nutrients. 2021 Sep 13;13(9):3182. doi: 10.3390/nu13093182. |
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| 27580947 | Background | Lin HS, Watts JN, Peel NM, Hubbard RE. Frailty and post-operative outcomes in older surgical patients: a systematic review. BMC Geriatr. 2016 Aug 31;16(1):157. doi: 10.1186/s12877-016-0329-8. |
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| 36645227 | Background | Fountotos R, Ahmad F, Bharaj N, Munir H, Marsala J, Rudski LG, Goldfarb M, Afilalo J. Multicomponent intervention for frail and pre-frail older adults with acute cardiovascular conditions: The TARGET-EFT randomized clinical trial. J Am Geriatr Soc. 2023 May;71(5):1406-1415. doi: 10.1111/jgs.18228. Epub 2023 Jan 16. |
| ID | Term |
|---|---|
| D006620 | Hip Fractures |
| D009043 | Motor Activity |
| D000073496 | Frailty |
| ID | Term |
|---|---|
| D005264 | Femoral Fractures |
| D050723 | Fractures, Bone |
| D014947 | Wounds and Injuries |
| D025981 | Hip Injuries |
| D007869 | Leg Injuries |
| D001519 | Behavior |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| ID | Term |
|---|---|
| D055070 | Resistance Training |
| ID | Term |
|---|---|
| D005081 | Exercise Therapy |
| D012046 | Rehabilitation |
| D000359 | Aftercare |
| D003266 | Continuity of Patient Care |
| D005791 | Patient Care |
| D013812 | Therapeutics |
| D026741 | Physical Therapy Modalities |
| D064797 | Physical Conditioning, Human |
| D015444 | Exercise |
| D009043 | Motor Activity |
| D009068 | Movement |
| D009142 | Musculoskeletal Physiological Phenomena |
| D055687 | Musculoskeletal and Neural Physiological Phenomena |
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