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Assessment of glucose metabolism and liver fat after 12 week dietary intervention in pre diabetes subjects. Subjects will be randomized to either high fat (olive oil supplemented),high carb/high fiber (beans supplemented) and high carb/low fiber diets. Glucose metabolism will be assessed by labeled oral glucose tolerance test and liver fat by magnetic resonance spectroscopy pre randomization and at 8 and 12 week after starting dietary intervention.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| high fat ( MUFA) diet | Experimental | intervention using high fat diet. |
|
| high carb/high fiber | Experimental | diet using high carb-high fiber with dry beans |
|
| high carb/low fat | Experimental | Habitual diet |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Dietary intervention | Dietary Supplement | three different diets ( high fat-low carb-low fiber/high carb-low fat - high fiber/high carb-low fat-low fiber) |
|
| Measure | Description | Time Frame |
|---|---|---|
| Changes in liver fat content after 12 weeks of intervention | 12 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Change in glucose metabolism after 12 weeks of intervention | 12 weeks |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Mayo clinic | Rochester | Minnesota | 55901 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 28323952 | Derived | Errazuriz I, Dube S, Slama M, Visentin R, Nayar S, O'Connor H, Cobelli C, Das SK, Basu A, Kremers WK, Port J, Basu R. Randomized Controlled Trial of a MUFA or Fiber-Rich Diet on Hepatic Fat in Prediabetes. J Clin Endocrinol Metab. 2017 May 1;102(5):1765-1774. doi: 10.1210/jc.2016-3722. |
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| ID | Term |
|---|---|
| D018149 | Glucose Intolerance |
| D005234 | Fatty Liver |
| ID | Term |
|---|---|
| D006943 | Hyperglycemia |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
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| ID | Term |
|---|---|
| D004035 | Diet Therapy |
| ID | Term |
|---|---|
| D044623 | Nutrition Therapy |
| D013812 | Therapeutics |
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| D008107 | Liver Diseases |
| D004066 | Digestive System Diseases |