Dietary Interventions in Prediabetes

The Effects of Dietary Supplementation on Hepatic Insulin Action and Glucose Tolerance in Pre-diabetes

Assessment of glucose metabolism and liver fat after 12 week dietary intervention in pre diabetes subjects. Subjects will be randomized to either high fat (olive oil supplemented),high carb/high fiber (beans supplemented) and high carb/low fiber diets. Glucose metabolism will be assessed by labeled oral glucose tolerance test and liver fat by magnetic resonance spectroscopy pre randomization and at 8 and 12 week after starting dietary intervention.

Inclusion Criteria:

• Impaired fasting glucose(100-125 mg/dl)
• HbA1c 5.7-6.4 %
• BMI 26-40 kg/sq.m

Exclusion Criteria:

• MRS contraindication
• Pregnant women
• Liver disease