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The aim of this study will be to evaluate in patients with type 2 diabetes the effects on liver fat of an intervention with a diet relatively rich in CHO/rich in fibre/low GI or a diet rich in MUFA, either combined or not with a structured program of physical exercise, with emphasis on mechanisms possibly underlining these effects, namely changes in postprandial triglyceride-rich lipoproteins, body fat distribution, insulin sensitivity, oxidative stress and inflammation, adipose tissue lipolytic activities, aerobic capacity and endothelial function.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| high fibre/low glycemic index diet - P A | Active Comparator | patients will follow for two months a diet high fibre/low glycemic index without physical activity program |
|
| Rich in MUFA diet - PA | Active Comparator | Patients will follow for two months a rich in MUFA diet without a physical activity program. |
|
| high fibre/low glycemic index diet+PA | Active Comparator | Patients will follow for two months a high fibre and low glycemic index diet associated with a physical activity program. |
|
| Rich in MUFA diet+PA | Active Comparator | Patients will follow for 2 months a rich in MUFA diet with a physical activity program. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Rich in MUFA diet -PA | Other | The patients will follow a rich in MUFA diet without a physical activity program. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Liver fat content | 0 and 8 weeks | |
| postprandial lipids metabolism | 0 and 8 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| changes in body fat distribution | 0 and 8 weeks | |
| oxidative stress and inflammation | 0 and 8 weeks | |
| adipose tissue lipolytic activities |
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Inclusion Criteria:
Exclusion Criteria:
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| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 27650287 | Derived | Bozzetto L, Costabile G, Luongo D, Naviglio D, Cicala V, Piantadosi C, Patti L, Cipriano P, Annuzzi G, Rivellese AA. Reduction in liver fat by dietary MUFA in type 2 diabetes is helped by enhanced hepatic fat oxidation. Diabetologia. 2016 Dec;59(12):2697-2701. doi: 10.1007/s00125-016-4110-5. Epub 2016 Sep 20. | |
| 24132660 | Derived |
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| high fiber/low glycemic index diet + pa | Other | patients will follow for two months a high fibre/ low glycemic index diet with a physical activity program. |
|
| Rich in MUFA diet+PA | Other | Patients will follow for two months a rich in MUFA diet with a physical activity program. |
|
| High fibre/low glycemic index diet-PA | Other | Patients will follow for two months a high fibre/low glycemic index diet without a physical activity program. |
|
| 0 and 8 weeks |
| Bozzetto L, Annuzzi G, Costabile G, Costagliola L, Giorgini M, Alderisio A, Strazzullo A, Patti L, Cipriano P, Mangione A, Vitelli A, Vigorito C, Riccardi G, Rivellese AA. A CHO/fibre diet reduces and a MUFA diet increases postprandial lipaemia in type 2 diabetes: no supplementary effects of low-volume physical training. Acta Diabetol. 2014;51(3):385-93. doi: 10.1007/s00592-013-0522-6. Epub 2013 Oct 17. |
| 22723581 | Derived | Bozzetto L, Prinster A, Annuzzi G, Costagliola L, Mangione A, Vitelli A, Mazzarella R, Longobardo M, Mancini M, Vigorito C, Riccardi G, Rivellese AA. Liver fat is reduced by an isoenergetic MUFA diet in a controlled randomized study in type 2 diabetic patients. Diabetes Care. 2012 Jul;35(7):1429-35. doi: 10.2337/dc12-0033. |
| ID | Term |
|---|---|
| D003924 | Diabetes Mellitus, Type 2 |
| D005234 | Fatty Liver |
| D009043 | Motor Activity |
| ID | Term |
|---|---|
| D003920 | Diabetes Mellitus |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
| D004700 | Endocrine System Diseases |
| D008107 | Liver Diseases |
| D004066 | Digestive System Diseases |
| D001519 | Behavior |
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