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| Name | Class |
|---|---|
| Danderyd Hospital | OTHER |
| Ersta Hospital, Sweden | OTHER |
| Karolinska University Hospital | OTHER |
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We want to asses the role of adipose tissue for metabolic complications to obesity before and after weight loss (surgery).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Obese | Other | Obese patients undergoing gastric by-pass surgery |
|
| Control group | Other | Cholecystectomy and anti-reflux surgery |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Obese | Other | gastric bypass |
| |
| Control group |
| Measure | Description | Time Frame |
|---|---|---|
| Insulin sensitivity, adipose tissue function and gene function | Performed with hyperinsulinemic euglycemic clamp before and two years after surgery. Subcutaneous and visceral fat biopsy at the time of surgery. | two years after surgery |
| Measure | Description | Time Frame |
|---|---|---|
| Body composition | DEXA (Dual-Energy X-ray absorptiometry), before and two years after surgery | two years after surgery |
| Vascular function | Non invasive ultrasound of vascular stiffness, before and two years after surgery |
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Inclusion Criteria obese:
Exclusion Criteria obese:
Inclusion Criteria non-obese controls:
Exclusion Criteria non-obese controls:
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| Name | Affiliation | Role |
|---|---|---|
| Erik Näslund, Prof. | Karolinska Institutet | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Ersta Hospital | Stockholm | 116 91 | Sweden | |||
| Karolinska University Hospital |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 33863803 | Derived | Mileti E, Kwok KHM, Andersson DP, Mathelier A, Raman A, Backdahl J, Jalkanen J, Massier L, Thorell A, Gao H, Arner P, Mejhert N, Daub CO, Ryden M. Human White Adipose Tissue Displays Selective Insulin Resistance in the Obese State. Diabetes. 2021 Jul;70(7):1486-1497. doi: 10.2337/db21-0001. Epub 2021 Apr 16. | |
| 29177471 | Derived |
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| ID | Term |
|---|---|
| D009765 | Obesity |
| ID | Term |
|---|---|
| D050177 | Overweight |
| D044343 | Overnutrition |
| D009748 | Nutrition Disorders |
| D009750 | Nutritional and Metabolic Diseases |
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| ID | Term |
|---|---|
| D050154 | Adiposity |
| D035061 | Control Groups |
| ID | Term |
|---|---|
| D050218 | Body Fat Distribution |
| D001837 | Body Weights and Measures |
| D001824 | Body Constitution |
| D010808 | Physical Examination |
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| Other |
Cholecystectomy and anti-reflux surgery |
|
| two years after surgery |
| Stockholm |
| 141 86 |
| Sweden |
| Danderyds Hospital | Stockholm | 182 88 | Sweden |
| Backdahl J, Andersson DP, Eriksson-Hogling D, Caidahl K, Thorell A, Mileti E, Daub CO, Arner P, Ryden M. Long-Term Improvement in Aortic Pulse Wave Velocity After Weight Loss Can Be Predicted by White Adipose Tissue Factors. Am J Hypertens. 2018 Mar 10;31(4):450-457. doi: 10.1093/ajh/hpx201. |
| D001835 |
| Body Weight |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D019937 |
| Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
| D001823 | Body Composition |
| D001669 | Biochemical Phenomena |
| D055598 | Chemical Phenomena |
| D008660 | Metabolism |
| D010829 | Physiological Phenomena |
| D015340 | Epidemiologic Research Design |
| D004812 | Epidemiologic Methods |
| D008919 | Investigative Techniques |
| D012107 | Research Design |
| D008722 | Methods |