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| Name | Class |
|---|---|
| University of Lausanne Hospitals | OTHER |
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Objectives:
The primary objective of this clinical trial is to characterize metabolic signatures associated with abdominal fat distribution in 40 women with different BMI 29-40 and different abdominal distribution of fat (visceral vs. sub-cutaneous fat).
No intervention with a product is planned. The subjects will be given one high fat meal with commercial products (eggs, milk, cream, bread, fruits, cheese and cheese) on one test day to test the post-prandial metabolic response.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| No product is tested | No intervention |
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| Measure | Description | Time Frame |
|---|---|---|
| Metabolic plasma, urine and faeces profiles as a function of fat mass distribution | Metabolic profiles of plasma, urine and feces samples are obtained by Nuclear Magnetic Resonance spectroscopy and Mass Spectrometry. Fat mass distribution is assessed using CT scan and DXA (Dual X-Ray Energy Absorptiometry). | Changes from baseline in metabolic profiles at one day following fat meal intake |
| Measure | Description | Time Frame |
|---|---|---|
| Insulin sensitivity | Insulin sensitivity is measured by oral glucose tolerance test | Measured on the day before the fat meal intake |
| Basal Energy Expenditure | Basal Energy Expenditure is measured by indirect calorimetry |
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Inclusion Criteria:
Exclusion Criteria:
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Obese women
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| Name | Affiliation | Role |
|---|---|---|
| Vittorio Giusti, MD, PD/MER | University Hospitals of Lausanne | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Nestlé Clinical Development Unit / Metabolic Unit | Lausanne | 1000 | Switzerland | |||
| University Hospitals, Service of endocrinology, diabetology, and metabolism |
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| ID | Term |
|---|---|
| D009765 | Obesity |
| ID | Term |
|---|---|
| D050177 | Overweight |
| D044343 | Overnutrition |
| D009748 | Nutrition Disorders |
| D009750 | Nutritional and Metabolic Diseases |
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| Basal Energy Expenditure is measured on the day preceding the fat meal intake |
| Lausanne |
| 1011 |
| Switzerland |
| D001835 |
| Body Weight |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |