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To investigate the effects of cortisol on heroin craving and stress reaction in heroin addicted subjects Randomized, double-blind, placebo-controlled, cross-over, single administration of study medication Study hypothesis:Cortisol has an inhibiting effect on heroin craving and stress reactivity in opioid dependent subjects.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| A | Other | Cortisol 20 mg /Placebo Mannitol |
|
| B | Other | Placebo Mannitol/Cortisol 20mg |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Cortisol 20 mg | Drug |
| ||
| Mannitol |
| Measure | Description | Time Frame |
|---|---|---|
| Heroin craving | outcome measures will be taken during the participants 2 test visit days. Each participant will stay for approx. 3 hours. | baseline, change from baseline during and after presentation of drug stimuli |
| Measure | Description | Time Frame |
|---|---|---|
| Anxiety | outcome measures will be taken during the participants 2 test visit days. Each participant will stay for approx. 3 hours. | baseline, change from baseline during and after presentation of drug stimuli |
| Measure | Description | Time Frame |
|---|---|---|
| Symptoms of withdrawal | outcome measures will be taken during the participants 2 test visit days. Each participant will stay for approx. 3 hours. | baseline, change from baseline during and after presentation of drug stimuli |
| saliva cortisol level |
Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Psychiatric Hospital | Basel | 4012 | Switzerland |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 26218852 | Derived | Walter M, Bentz D, Schicktanz N, Milnik A, Aerni A, Gerhards C, Schwegler K, Vogel M, Blum J, Schmid O, Roozendaal B, Lang UE, Borgwardt S, de Quervain D. Effects of cortisol administration on craving in heroin addicts. Transl Psychiatry. 2015 Jul 28;5(7):e610. doi: 10.1038/tp.2015.101. |
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| ID | Term |
|---|---|
| D009293 | Opioid-Related Disorders |
| ID | Term |
|---|---|
| D000079524 | Narcotic-Related Disorders |
| D019966 | Substance-Related Disorders |
| D064419 | Chemically-Induced Disorders |
| D001523 | Mental Disorders |
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| ID | Term |
|---|---|
| D006854 | Hydrocortisone |
| D008353 | Mannitol |
| ID | Term |
|---|---|
| D011282 | Pregnenediones |
| D011283 | Pregnenes |
| D011278 | Pregnanes |
| D013256 | Steroids |
| D000072473 |
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Mannitol used as placebo |
|
outcome measures will be taken during the participants 2 test visit days. Each participant will stay for approx. 3 hours.
| baseline, change from baseline during and after presentation of drug stimuli |
| Fused-Ring Compounds |
| D011083 | Polycyclic Compounds |
| D015062 | 11-Hydroxycorticosteroids |
| D006889 | Hydroxycorticosteroids |
| D000305 | Adrenal Cortex Hormones |
| D006728 | Hormones |
| D006730 | Hormones, Hormone Substitutes, and Hormone Antagonists |
| D015065 | 17-Hydroxycorticosteroids |
| D013402 | Sugar Alcohols |
| D000438 | Alcohols |
| D009930 | Organic Chemicals |
| D002241 | Carbohydrates |