Effect of Stress on Heroin-Related Memory Retrieval
ClinicalTrials.gov ID
NCT00759005
Lead Sponsor
National Institute on Drug Dependence, ChinaOTHER
Overall Status
Completed
Study Type
Interventional
Phase
Not Applicable
Last Update Posted
Sep 25, 2008Estimated
Start Date
Mar 2007
Primary Completion Date
Jun 2008Actual
Completion Date
Sep 2008Actual
Brief Summary
The purpose of this study is to determine whether cortisol and propranolol are effective in the modulation of stress induced heroin-related retrieval enhancement.
Heroin Dependence
Learning and Memory
propranolol and cortisol
Ages Eligible for Study
Adult (18-64)
Sexes Eligible for Study
Male
Accepts Healthy Volunteers
No
Eligibility Criteria
Inclusion Criteria:
Participants had to have met DSM-IV criteria for heroin dependence prior to abstinence.
Exclusion Criteria:
current use of any medications; current DSM-IV diagnosis of any affective, anxiety, or psychotic disorder; current dependence on any substance besides heroin and nicotine (based on DSM-IV criteria); or risk factors for untoward side effects from propranolol and cortisol (i.e., irregular heartbeats, history of cardiogenic shock, history of severe heart failure, asthma, fungal Infections, hyperlipidemia, history of hypertension, or abnormal ECG or other laboratory findings).