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| Name | Class |
|---|---|
| Marquette University | OTHER |
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Topical menthol gels are classified 'topical analgesics' and are used to relieve pain of the musculoskeletal system. However, double-blind randomized controlled trials are lacking. Here the investigators examine - in a double-blind randomized controlled cross-over trial - the acute effect of topical menthol (Biofreeze) and placebo (gel with a menthol scent) on pain symptoms in slaughterhouse workers with symptoms of Carpal Tunnel Syndrome.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Menthol | Experimental | Biofreeze topical gel containing 3.5% menthol |
|
| Placebo | Placebo Comparator | Topical gel containing a menthol scent, but no active menthol |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Menthol | Other | The gel will be applied at 2.5 ml per 500 cm2 to the hand, wrist and forearm |
|
| Measure | Description | Time Frame |
|---|---|---|
| Change in arm/hand pain intensity (scale 0-10) during work | the participant rates "pain intensity during the last hour" on a scale from 0-10 immediately before, and 1,2,3 hours after application of the gel. The primary outcome is the change from before to after (average of 1,2 and 3 hours after) application of the gel | change from before to after (average of 1,2 and 3 hours after) application of the gel |
| Measure | Description | Time Frame |
|---|---|---|
| GROC | Global Rating of Change (GROC) on a scale from - 5(much worsening of pain) to 5(much improvement of pain) | 3 hours after application of the gel |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Lars L Andersen, PhD | Professor | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| National Research Centre for the Working Environment | Copenhagen | 2100 | Denmark |
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| ID | Term |
|---|---|
| D002349 | Carpal Tunnel Syndrome |
| ID | Term |
|---|---|
| D020423 | Median Neuropathy |
| D020422 | Mononeuropathies |
| D010523 | Peripheral Nervous System Diseases |
| D009468 | Neuromuscular Diseases |
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| ID | Term |
|---|---|
| D008610 | Menthol |
| D000700 | Analgesics |
| ID | Term |
|---|---|
| D003511 | Cyclohexanols |
| D000441 | Hexanols |
| D005233 | Fatty Alcohols |
| D000438 | Alcohols |
| D009930 |
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| Placebo | Other | The gel will be applied at 2.5 ml per 500 cm2 to the hand, wrist and forearm |
|
| D009422 | Nervous System Diseases |
| D009408 | Nerve Compression Syndromes |
| D012090 | Cumulative Trauma Disorders |
| D013180 | Sprains and Strains |
| D014947 | Wounds and Injuries |
| Organic Chemicals |
| D000081005 | Cyclohexane Monoterpenes |
| D003510 | Cyclohexanes |
| D003516 | Cycloparaffins |
| D006840 | Hydrocarbons, Alicyclic |
| D006844 | Hydrocarbons, Cyclic |
| D006838 | Hydrocarbons |
| D039821 | Monoterpenes |
| D013729 | Terpenes |
| D008055 | Lipids |
| D018689 | Sensory System Agents |
| D018373 | Peripheral Nervous System Agents |
| D045505 | Physiological Effects of Drugs |
| D020228 | Pharmacologic Actions |
| D020164 | Chemical Actions and Uses |
| D002491 | Central Nervous System Agents |
| D045506 | Therapeutic Uses |