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| Name | Class |
|---|---|
| Marquette University | OTHER |
| Sport and Spine Rehab Clinical Research Foundation | OTHER |
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Topical menthol gels are classified 'topical analgesics' and are used to relieve aching and tenderness of muscles and joints. However, double-blind randomized controlled trials are lacking. Here the investigators examine - in a double-blind randomized controlled cross-over trial - the acute effect of topical menthol (Biofreeze) and placebo (gel with a menthol scent) on neck pain.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Placebo | Placebo Comparator | Topical gel containing a menthol scent, but no active menthol |
|
| Biofreeze | Experimental | Biofreeze topical gel containing 3.5% menthol |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Biofreeze | Other | The gel will be applied at 2.5 ml per 500 cm2 to the upper trapezius and neck muscles by a gloved technician |
|
| Measure | Description | Time Frame |
|---|---|---|
| Neck pain intensity (scale 0-10) | the participant rates pain intensity on a scale from 0-10 immediately before, and 0, 10, 20, 40 and 60 minutes after application of the gel. The primary efficacy endpoint is at 20 min | before and 20 min after application |
| Measure | Description | Time Frame |
|---|---|---|
| Pressure pain threshold (PPT) | pressure pain threshold of the upper trapezius muscle is measured by a handheld algometer immediately before, and 0, 10, 20, 40 and 60 minutes after application of the gel. | before and 20 min after application |
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Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Lars L Andersen, PhD | Professor | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| National Research Centre for the Working Environment | Copenhagen | 2100 | Denmark |
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| Label | URL |
|---|---|
| Company website | View source |
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| ID | Term |
|---|---|
| D009140 | Musculoskeletal Diseases |
| D019547 | Neck Pain |
| ID | Term |
|---|---|
| D010146 | Pain |
| D009461 | Neurologic Manifestations |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| ID | Term |
|---|---|
| D000700 | Analgesics |
| ID | Term |
|---|---|
| D018689 | Sensory System Agents |
| D018373 | Peripheral Nervous System Agents |
| D045505 | Physiological Effects of Drugs |
| D020228 | Pharmacologic Actions |
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| Placebo | Other | The gel will be applied at 2.5 ml per 500 cm2 to the upper trapezius and neck muscles by a gloved technician |
|
| D020164 | Chemical Actions and Uses |
| D002491 | Central Nervous System Agents |
| D045506 | Therapeutic Uses |