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This study investigates if/how an experimentally applied muscle pain/soreness, lasting for some days may affect brain activity, balance, movement patterns, muscle function and pain sensitivity in a healthy population
All included healthy volunteers will participate in test-sessions on 4 separate days over approximately 2 weeks.
During the study participants will be randomised into and either a control group (injection of isotonic saline into a neck muscle) or neck pain group (injection of Nerve Growth Factor (NGF) into a neck muscle).
Alle participants tested with regards to:
Brain activity related to neck muscles will be estimated using TMS Balance will be tested using a force place Body movements will be recorded using 3D tracking Muscle activity will be estimated using electromyography (EMG)
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Control group | Experimental | Participants will be injected with 0.5ml Isotonic saline into a neck muscle |
|
| Neck pain | Experimental | Participants will be injected with 0.5ml NGF into the a neck muscle |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Injection of Isotonic saline | Other | Half the participants will be injected in a neck muscle with isotonic saline (Control group) and the other half will get NGF (Neck pain group). |
| Measure | Description | Time Frame |
|---|---|---|
| Change in pressure pain threshold (PPT) measured with a handheld pressure algometer | PPT will be assessed over head, neck, arm and leg sites. | Day 0, 2,4 and 15 |
| Change in motor evoked potentials | Trans cranial magnetic stimulation (TMS) is used to asses motor evoked potentials of neck muscles | Day 0, 4 and 15 |
| Change in Body movement | 3D recordings of body movements | Day 0, 4 and 15 |
| Measure | Description | Time Frame |
|---|---|---|
| Change in muscle activity (EMG) | EMG of axioscapular muscles & trunk during arm movements | Day 0, 4 and 15 |
| Change in standing balance | Standing balance is measured on a force platform |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Steffan W Christensen, PhD | Contact | +45 99408889 | stc@hst.aau.dk |
| Name | Affiliation | Role |
|---|---|---|
| Steffan W Christensen, PhD | Aalborg University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Dept. Of Health Science and Technology, SMI, Aalborg University | Recruiting | Aalborg | 9220 | Denmark |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 36584579 | Derived | Simonsen MB, Cancino EE, de Brito Silva P, Sorensen LB, Hirata RP, Christensen SWM. The impact of prolonged experimental neck pain on walking stability and gait kinematics - A parallel-group study. Clin Biomech (Bristol). 2023 Jan;101:105869. doi: 10.1016/j.clinbiomech.2022.105869. Epub 2022 Dec 23. |
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| ID | Term |
|---|---|
| D019547 | Neck Pain |
| ID | Term |
|---|---|
| D010146 | Pain |
| D009461 | Neurologic Manifestations |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| Injection of NGF | Other | Half the participants will be injected in a neck muscle with NGF (Neck pain group). |
|
| Day 0, 4 and 15 |
| Change in perceived pain: McGill Pain Questionnaire | Pain will be scored using a scale from 0-10 with 0 being no pain and 10 being worst imaginable pain, by drawing on body charts and choosing words from the McGill Pain Questionnaire. | Day 0, 2,4 and 15 |
| Disability | Neck disability Index will be scored. Body movements will be scored on a modified 6-point Likert scale (0 = not difficult at all; 1 = minimally difficult; 2 = somewhat difficult; 3 = fairly difficult; 4 = very difficult; 5 = unable to perform) | Day 0, 2,4 and 15 |
| Pain Catastrophizing Scale (13 item questionnaire) | Pain Catastrophizing Scale (PCS) questionnaire. 13 items that can be answered with a Likert scale (0 = not at all, 1 = to a slight degree, 2= to a moderate degree, 3 = to a great degree, 4 = all the time). The PCS is scored by summing responses to all 13 items with scores ranging from 0 - 52. | Day 2 |
| The Big Five Inventory (BFI) | BFI questionnaire investigates five general traits personality: extraversion, agreeableness, conscientiousness, neuroticism and openness. The BFI consists of 44 items that are answered on a 5 point Likert scale (1=Disagree strongly, 2=Disagree a little, 3=Neither agree or disagree, 4=Agree a little, 5=Agree strongly). This is not good/bad score in this questionnaire as it only assess personality traits. | Day 2 |