Palmitic Acid in the Sn-2 Position of Triacylglycerols and Postprandial Lipemia

The purpose of this study is to determine whether high-fat meals rich in palmitic acid in the sn-2 position decrease lipaemia in men aged 40-70 y with higher than optimal fasting triacylglycerol concentrations.

Inclusion Criteria:

• Healthy males
• Non-smokers
• Aged 40-70 years
• Fasting TAG concentrations ≥1.5 mmol/L.

Exclusion Criteria:

• Reported history of CVD (myocardial infarction, angina, venous thrombosis, stroke), impaired fasting glucose/uncontrolled type 2 diabetes (or fasting glucose ≥ 6.1 mmol/L), cancer, kidney, liver or bowel disease.
• Presence of gastrointestinal disorder or use of drug, which is likely to alter gastrointestinal motility or nutrient absorption.
• History of substance abuse or alcoholism (previous weekly alcohol intake >60 units/men)
• Current self-reported weekly alcohol intake exceeding 28 units
• Allergy or intolerance to any component of test meals
• Unwilling to restrict consumption of any source of fish oil for the length of the study
• Weight change of >3kg in preceding 2 months
• Body Mass Index <20 and >35 kg/m2
• Fasting blood cholesterol > 7.8 mmol/L
• Current cigarette smoker.
• Current use of lipid lowering medication