Efficacy of Midodrine for the Prevention of Orthostatic Hypotension During Early Mobilization After Fast-track Hip Arthroplasty

Efficacy of Midodrine for the Prevention of Orthostatic Hypotension During Early Mobilization After Fast-track Hip Arthroplasty - a Randomized, Placebo Controlled Trial.

The aim of this study is to examine the efficacy of 5 mg Midodrine (Gutron) vs. placebo on reducing the incidence of orthostatic hypotension during mobilization 6 h after a total hip arthroplasty.

Inclusion Criteria:

• Scheduled for primary unilateral hip arthroplasty
• Age >= 18 years
• Able to give informed consent

Exclusion Criteria:

• General anaesthesia for the current procedure
• Digoxin treatment.
• history of renal or hepatic failure
• history of glaucoma
• history chronic urinary retention requiring treatment
• history of orthostatic intolerance / hypotension
• other autonomous nervous system disease
• alcohol or drug abuse
• current malignant disease
• females in the fertile age (possible pregnancy or breast feeding)
• Treatment with anticoagulants
• BMI > 40 kg/m2
• Dementia or cognitive dysfunction (investigators evaluation)