Clinical Pharmacokinetics Study of ART-123 in Disseminated Intravascular Coagulation (DIC) Subjects With Renal Impairment

A Post-Marketing Clinical Pharmacokinetics Study of ART-123 in DIC Subjects With Renal Impairment

To investigate the impact of impaired renal function on the pharmacokinetics of ART-123 in patients with Disseminated Intravascular Coagulation.

To investigate the safety of ART-123 in patients with Disseminated Intravascular Coagulation.

Inclusion Criteria:

• Japanese Association for Acute Medicine-defined DIC criteria score >= 4
• Written informed consent from patient or guardian

Exclusion Criteria:

• Patients showing intracranial, pulmonary, gastrointestinal hemorrhage
• Patients with a history of cerebrovascular disorders within the past 52 week
• Patients with a history of hypersensitivity to the ingredients of ART-123 preparations
• Pregnant women, nursing mothers or possibly pregnant women