The purpose of this study is to see if ART-123 (recombinant human soluble thrombomodulin) decreases the number of people who die as a result of Disseminated Intravascular Coagulation (DIC) complication of sepsis.

Inclusion Criteria:

• Infection or suspected infection resulting in sepsis and DIC

Exclusion Criteria:

• Unable to provide informed consent, or lack of consent from an acceptable surrogate
• Subjects < 18 years of age
• Known conditions that could confound the diagnosis of DIC due to sepsis
• Known conditions that increase the risk of bleeding
• Known medical condition associated with a hypercoagulable state
• Known or suspected severe liver disease
• History of solid organ (excluding uncomplicated kidney), bone marrow or stem cell transplantation
• Renal failure