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Women with Hypoactive sexual desire disorder (HSDD) have all measures of testosterone activity comparable to controls but lower levels of dehydroepiandrosterone (DHEA). Although DHEA is a precursor of testosterone it has other actions including involvement in the stress system. It is also linked to mood. This study focuses on measures of childhood stress, current mood and salivary stress hormones, in women with and without HSDD. We hypothesize that low levels of DHEA reflect dysfunction of the neuroendocrine stress response system involving the brain, pituitary and adrenal glands where DHEA is produced.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| HSDD group | Women with a diagnosis of Hypoactive Sexual Desire Disorder (HSDD). | ||
| Control Group | Women without a diagnosis of Hypoactive Sexual Desire Disorder (HSDD). |
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| Measure | Description | Time Frame |
|---|---|---|
| DHEA levels | DHEA levels derived from saliva samples. | Data is collected at 4 time points on 3 separate days |
| Measure | Description | Time Frame |
|---|---|---|
| Cortisol levels | Cortisol levels derived from saliva samples. | Data is collected at 4 time points on 3 separate days |
| Depression | Depression will be measured by the Beck Depression Inventory (Beck & Beamesderfer, 1974) |
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Inclusion Criteria for HSDD Group:
Inclusion criteria for Control group:
Exclusion Criteria for both Control and HSDD groups:
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Women with and without a diagnosis of Hypoactive Sexual Desire Disorder (HSDD).
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| Name | Affiliation | Role |
|---|---|---|
| Rosemary Basson, MD | University of British Columbia | Principal Investigator |
| Lori A Brotto, PhD | University of British Columbia | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| British Columbia Centre for Sexual Medicine | Vancouver | British Columbia | V6T 1Z9 | Canada |
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| Label | URL |
|---|---|
| UBC Sexual Health Lab | View source |
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| ID | Term |
|---|---|
| D020018 | Sexual Dysfunctions, Psychological |
| ID | Term |
|---|---|
| D001523 | Mental Disorders |
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saliva samples
| data is collected at single time point |
| Perceived stress | Perceived stress will be measured with the 10-item Perceived Stress Scale (Roberti, Harrington & Storch 2006) | data is collected at a single time point |
| Sexual function | Self-report sexual function will be measured with the Sexual Interest and Desire Inventory (Clayton et al. 2006)) | data is collected at a single time point |
| Relationship satisfaction | Relationship satisfaction will be measured with the Relationship Assessment Scale (Hendrick, 1988) and the Dyadic Adjustment Scale (Spanier, 1976) | data is collected at a single time point |
| History of childhood trauma | History of childhood trauma will be determined with the Childhood Trauma Questionnaire (Bernstein & Fink, 1995) | dat is collected at a single timepoint |
| History of childhood sexual abuse | History of Childhood Sexual Abuse will be determined with the Childhood Sexual Abuse Measure (Finkelhor, 1979) | data is collected at a single time point |
| PTSD symptoms | Presence and severity of post traumatic stress disorder symptoms will be determined through the Clinician-Administered PTSD Scale (Blake et al. 1998) | data is collected at a single time point |